Evidence map›Paper›PMID 26566060›Full record

ArticleTransplantation2016

APOL1 Genotype and Kidney Transplantation Outcomes From Deceased African American Donors.

Barry I Freedman, Stephen O Pastan, Ajay K Israni, David Schladt, Bruce A Julian, Michael D Gautreaux, Vera Hauptfeld, Robert A Bray, Howard M Gebel, Allan D Kirk and 15 more

Registry-linked trialAbstract read
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In one paragraph

Article in Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03615235 (APOL1 Long-term Kidney Transplantation Outcomes Network), which is not on this map. Cited by 100 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03615235 active not recruitingnot on this mapstarted 2019, after this paper: background citation

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

TypeobservationalSponsorWake Forest University Health SciencesRan2019 to 2027Enrolled5,000ConditionsKidney Diseases, Kidney Failure, Kidney Disease, Chronic
3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
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  14. Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024
    Article
  15. Review
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  18. Monogenic Kidney Diseases in Kidney Transplantation.Kidney international reports · 2024
    Review
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Barry I Freedman1 Section on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC. 2 Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC. 3 Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA. 4 Division of Nephrology, Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN. 5 Minneapolis Medical Research Foundation, Minneapolis, MN. 6 Division of Nephrology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL. 7 General Surgery and HLA Immunogenetics Laboratory, Wake Forest School of Medicine, Winston-Salem, NC. 8 Alabama Regional Histocompatibility Laboratory at UAB, University of Alabama at Birmingham School of Medicine, Birmingham, AL. 9 Department of Pathology and Laboratory Medicine; Emory School of Medicine, Atlanta, GA. 10 Department of Surgery, Duke University School of Medicine, Durham, NC. 11 Department of General Surgery, Wake Forest School of Medicine, Winston-Salem, NC. 12 Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, New York, NY. 13 Division of Public Health Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC.
Stephen O Pastan
Ajay K Israni
David Schladt
Bruce A Julian
Michael D Gautreaux
Vera Hauptfeld
Robert A Bray
Howard M Gebel
Allan D Kirk
Robert S Gaston
Jeffrey Rogers
Alan C Farney
Giuseppe Orlando
Robert J Stratta
Sumit Mohan
Lijun Ma
Carl D Langefeld
Donald W Bowden
Pamela J Hicks
Nicholette D Palmer
Amudha Palanisamy
Amber M Reeves-Daniel
W Mark Brown
Jasmin Divers

Funding

Pharmacogenomics of Immune Suppressants in Kidney TransplantationU19AI070119 · NIAID · UNIVERSITY OF MINNESOTA · PI MATAS, ARTHUR J · 2006 to 2016
$17.1M
Genetic Analysis of African American Hypertensive End-Stage Renal DiseaseR01DK070941 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2006 to 2015
$4.7M
Natural History of MYH9-Associated NephropathyR01DK084149 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2009 to 2012
$2.3M
Genetic Determinants of Renal Transplant Survival from African American DonorsR01MD009055 · NIMHD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DIVERS, JASMIN, FREEDMAN, BARRY IRA · 2014 to 2018
$2.0M
NIAID NIH HHS 5U19-AI070119NIAID NIH HHS U19 AI070119NIDDK NIH HHS R01 DK070941NIDDK NIH HHS R01 DK084149NIMHD NIH HHS R01 MD009055
6 · The paper itself

Abstract

backgroundTwo apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 renal-risk variants were genotyped in additional AA kidney donors.

methodsThe APOL1 genotypes were linked to outcomes in 478 newly analyzed DDKTs in the Scientific Registry of Transplant Recipients. Multivariate analyses accounting for recipient age, sex, race, panel-reactive antibody level, HLA match, cold ischemia time, donor age, and expanded criteria donation were performed. These 478 transplantations and 675 DDKTs from a prior report were jointly analyzed.

resultsFully adjusted analyses limited to the new 478 DDKTs replicated shorter renal allograft survival in recipients of APOL1 2-renal-risk-variant kidneys (hazard ratio [HR], 2.00; P = 0.03). Combined analysis of 1153 DDKTs from AA donors revealed donor APOL1 high-risk genotype (HR, 2.05; P = 3 × 10), older donor age (HR, 1.18; P = 0.05), and younger recipient age (HR, 0.70; P = 0.001) adversely impacted allograft survival. Although prolonged allograft survival was seen in many recipients of APOL1 2-renal-risk-variant kidneys, follow-up serum creatinine concentrations were higher than that in recipients of 0/1 APOL1 renal-risk-variant kidneys. A competing risk analysis revealed that APOL1 impacted renal allograft survival, but not recipient survival. Interactions between donor age and APOL1 genotype on renal allograft survival were nonsignificant.

conclusionsShorter renal allograft survival is reproducibly observed after DDKT from APOL1 2-renal-risk-variant donors. Younger recipient age and older donor age have independent adverse effects on renal allograft survival.

Indexed as

Kidney TransplantationTissue DonorsAdultAge FactorsAllograftsApolipoprotein L1ApolipoproteinsBiomarkersBlack or African AmericanChi-Square DistributionCreatinineFemaleGenotypeGraft SurvivalHumansKaplan-Meier EstimateAPOL1 protein, humanApolipoprotein L1ApolipoproteinsBiomarkersCreatinineLipoproteins, HDL

Identifiers

PMID26566060
PMCPMC4684443

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.