ArticleAmerican journal of respiratory and critical care medicine2016
Membrane and Capillary Components of Lung Diffusion in Infants with Bronchopulmonary Dysplasia.
Article in American journal of respiratory and critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- The evolving pathophysiology of bronchopulmonary dysplasia.Physiological reviews · 2026Review
- Physiologic Pulmonary Phenotyping of Infants Born Preterm and Post-Discharge Respiratory Morbidity.The Journal of pediatrics · 2025Article
- Cord blood stem cell‑derived Angptl7 ameliorates the severity of bronchopulmonary dysplasia via anti‑inflammatory and proangiogenic effects.Molecular medicine reports · 2024Article
- Regular soccer training improves pulmonary diffusion capacity in 6 to 10 year old boys.BMC sports science, medicine & rehabilitation · 2023Article
- Defining and Promoting Pediatric Pulmonary Health: Assessing Lung Function and Structure.Pediatrics · 2023Article
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Development of lung diffusion to adulthood following extremely preterm birth.The European respiratory journal · 2022Article
- Bronchopulmonary dysplasia as a determinant of respiratory outcomes in adult life.Pediatric pulmonology · 2021Article
- Lung growth and pulmonary function after prematurity and bronchopulmonary dysplasia.Pediatric pulmonology · 2021Review
- Understanding hydrogen sulfide signaling in neonatal airway disease.Expert review of respiratory medicine · 2021Review
- Bronchopulmonary Dysplasia: Then, Now, and Next.Pediatric allergy, immunology, and pulmonology · 2020Review
- Phenotypes of Bronchopulmonary Dysplasia.International journal of molecular sciences · 2020Review
- Cumulative effects of neonatal hyperoxia on murine alveolar structure and function.Pediatric pulmonology · 2017Article
- Ventilatory Efficiency in Children and Adolescents Born Extremely Preterm.Frontiers in physiology · 2017Article
- Bronchopulmonary dysplasia: what are its links to COPD?Therapeutic advances in respiratory diseaseReview
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAutopsied lungs of infants with bronchopulmonary dysplasia (BPD) demonstrate impaired alveolar development with larger and fewer alveoli, which is consistent with our previous physiologic findings of lower pulmonary diffusing capacity of the lung for carbon monoxide (DL(CO)) in infants and toddlers with BPD compared with healthy controls born at full term (FT). However, it is not known whether the decreased DL(CO) in infants with BPD results from a reduction in both components of DL(CO): pulmonary membrane diffusing capacity (D(M)) and Vc.
objectivesWe hypothesized that impairment of alveolar development in BPD results in a decrease in both D(M) and Vc components of DlCO but that the D(M)/Vc ratio would not differ between the BPD and FT groups.
methodsDL(CO) was measured under conditions of room air and high inspired oxygen (90%), which enabled D(M) and Vc to be calculated. MEASUREMENTS AND MAIN
resultsD(M) and Vc increased with increasing body length; however, infants with BPD had significantly lower D(M) and Vc than FT subjects after adjustment for race, sex, body length, and corrected age. In contrast to D(M) and Vc, the D(M)/Vc ratio remained constant with increasing body length and did not differ for infants with BPD and FT subjects.
conclusionsOur findings are consistent with infants with BPD having impaired alveolar development with fewer but larger alveoli, as well as a reduced Vc.
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