ArticleCell reports2015
A Diencephalic Dopamine Source Provides Input to the Superior Colliculus, where D1 and D2 Receptors Segregate to Distinct Functional Zones.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Reflexive eye movement alterations are related to subclinical impulsive-compulsive behaviors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.Nature communications · 2026Article
- Smooth pursuit eye movements in different directions and frequencies as biomarkers for detecting early stage Parkinson's disease and assessing levodopa responsiveness: a cross-sectional study.European journal of medical research · 2025Observational
- Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models.eLife · 2025Article
- Sensitive dLight3 for imaging broad-spectrum dopamine events across brain regions.Research square · 2025Article
- Eye movement parameters as biomarkers for diagnosis and levodopa responsiveness in patients with Parkinson's disease.Aging clinical and experimental research · 2025Article
- Brainwide Projections of Mouse Dopaminergic Zona Incerta Neurons.The Journal of comparative neurology · 2025Article
- Characterize neuronal responses to natural movies in the mouse superior colliculus.Frontiers in cellular neuroscience · 2025Article
- Article
- Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.Cell reports · 2024Article
- Inhibitory medial zona incerta pathway drives exploratory behavior by inhibiting glutamatergic cuneiform neurons.Nature communications · 2024Article
- Connecting the dots in the zona incerta: A study of neural assemblies and motifs of inter-area coordination in mice.iScience · 2024Article
- Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neural Circuit Mechanisms Involved in Animals' Detection of and Response to Visual Threats.Neuroscience bulletin · 2023Review
- Medication only improves limb movements while deep brain stimulation improves eye and limb movements during visually-guided reaching in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- Medication adversely impacts visually-guided eye movements in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- From retina to motoneurons: A substrate for visuomotor transformation in salamanders.The Journal of comparative neurology · 2022Article
- Dopamine modulates visual threat processing in the superior colliculus via D2 receptors.iScience · 2022Article
- Effects of Light Isoflurane Anesthesia on Organization of Direction and Orientation Selectivity in the Superficial Layer of the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of neural responses is frequently observed in the superior colliculus (SC), a retinorecipient midbrain structure that controls orienting and the localization of attention. Although behavioral contingencies that influence SC responses are well documented, the neural pathways and molecular mechanisms responsible for this modulation are not completely understood. Here, we illustrate a dopaminergic system that strongly impacts neural responses in the SC. After using RNA sequencing (RNA-seq) to detail the transcriptome of dopamine-related genes in the SC, we show that D1 receptors are enriched in the superficial visual SC, while D2 receptors segregate to the intermediate multimodal/motor SC. Retrograde injections into the SC consistently label A13, a small dopamine cell group located in the zona incerta. We surmise that A13 mimics dopaminergic effects that we observed in SC slices, which suggests that dopamine in the SC may reduce the tendency of an animal to orient or attend to salient stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.