ArticlePloS one2015
Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- mApplied biochemistry and biotechnology · 2026Article
- Early life bacteria and sibling exposure associate with restoration of the infant gut microbiome after cesarean section.Nature communications · 2026Article
- Explore Alteration of Lung and Gut Microbiota in a Murine Model of OVA-Induced Asthma Treated by CpG Oligodeoxynucleotides.Journal of inflammation research · 2025Article
- Management of a pregnant woman with a large cervical polyp and moderate genital bleeding in the first trimester.BMJ case reports · 2024Article
- The gut-lung axis in critical illness: microbiome composition as a predictor of mortality at day 28 in mechanically ventilated patients.BMC microbiology · 2023Observational
- Review
- Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema.Antioxidants (Basel, Switzerland) · 2022Article
- Fecal Microbiota Transplantation Controls Progression of Experimental Autoimmune Hepatitis in Mice by Modulating the TFR/TFH Immune Imbalance and Intestinal Microbiota Composition.Frontiers in immunology · 2021Article
- Maternal vitamin D deficiency impairs Treg and Breg responses in offspring mice and deteriorates allergic airway inflammation.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.Shock (Augusta, Ga.) · 2019Article
- Contributions of the intestinal microbiome in lung immunity.European journal of immunology · 2018Review
- Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients.International journal of biological sciences · 2018Article
- Pig Farmers' Homes Harbor More Diverse Airborne Bacterial Communities Than Pig Stables or Suburban Homes.Frontiers in microbiology · 2018Article
- Emerging pathogenic links between microbiota and the gut-lung axis.Nature reviews. Microbiology · 2017Review
- Early Postnatal Exposure to Cigarette Smoke Leads to Later Airway Inflammation in Asthmatic Mice.PloS one · 2017Article
- 'Neglecta timonensis' gen. nov., sp. nov., a new human-associated species.New microbes and new infections · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLow Clostridium leptum levels are a risk factor for the development of asthma. C. leptum deficiency exacerbates asthma; however, the impact of early-life C. leptum exposure on cesarean-delivered mice remains unclear. This study is to determine the effects of early-life C. leptum exposure on asthma development in infant mice.
methodsWe exposed infant mice to C. leptum (fed-CL) and then induced asthma using the allergen ovalbumin (OVA).
resultsFed-CL increased regulatory T (Treg) cells in cesarean-delivered mice compared with vaginally delivered mice. Compared with OVA-exposed mice, mice exposed to C. leptum + OVA did not develop the typical asthma phenotype, which includes airway hyper-responsiveness, cell infiltration, and T helper cell subset (Th1, Th2, Th9, Th17) inflammation. Early-life C. leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells, resulting in the inhibition of Th1, Th2, Th9, and Th17 cell responses.
conclusionThese findings demonstrate a mechanism whereby C. leptum exposure modulates adaptive immunity and leads to failure to develop asthma upon OVA sensitization later in life.
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