ArticleScientific reports2015
Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Macrophages in Ulcerative Colitis: Immunomodulatory Roles, Phenotypic Switching, and Therapeutic Targeting.Journal of innate immunity · 2026Review
- Macrophages reprogramming improves immunotherapy of IL-33 in peritoneal metastasis of gastric cancer.EMBO molecular medicine · 2024Article
- Role of histamine-mediated macrophage differentiation in clearance of metastatic bacterial infection.Frontiers in immunology · 2023Article
- CXCL13 is elevated in inflammatory bowel disease in mice and humans and is implicated in disease pathogenesis.Frontiers in immunology · 2022Article
- Intraperitoneally Delivered Mesenchymal Stem Cells Alleviate Experimental Colitis Through THBS1-Mediated Induction of IL-10-Competent Regulatory B Cells.Frontiers in immunology · 2022Article
- Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury.Nature communications · 2021Article
- A missense variant inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Impact of anatomic site on antigen-presenting cells in cancer.Journal for immunotherapy of cancer · 2020Review
- PAM3 protects against DSS-induced colitis by altering the M2:M1 ratio.Scientific reports · 2020Article
- TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells.Journal of biomedical science · 2019Article
- Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses.Frontiers in immunology · 2019Article
- Abdominal paracentesis drainage ameliorates severe acute pancreatitis in rats by regulating the polarization of peritoneal macrophages.World journal of gastroenterology · 2018Article
- Clinical Evaluations of Toxicity and Efficacy of Nanoparticle-Mediated Gene Therapy.Human gene therapy · 2018Review
- Rab32-related antimicrobial pathway is involved in the progression of dextran sodium sulfate-induced colitis.FEBS open bio · 2018Article
- Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease?Inflammatory bowel diseases · 2018Review
- The Peritoneal Macrophages in Inflammatory Diseases and Abdominal Cancers.Oncology research · 2018Review
- MicroRNA-126 deficiency enhanced the activation and function of CD4Clinical and experimental immunology · 2018Article
- Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice.Scientific reports · 2017Article
- M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T-cell proliferation.Immunology · 2016Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adoptive transfer of the natural regulatory B cells and macrophages should be a useful treatment for inflammation and autoimmune disease. However, it is usually difficult to isolate these cells from the tissues and expand them. Here, we investigated the feasibility of adoptively transferring peritoneal cells (PCs) as a treatment for DSS-induced colitis. We found that peritoneal cavity can provide an easily accessible site for harvesting enough number of PCs, namely, two-dose PCs for the treatment from a mouse in one operation. Adoptive therapy of these cells from healthy mice or those with disease is effectively in reducing the disease activity score. The natural B cells and macrophages of the infused PCs can selectively migrate to lesion sites and regulate the expression of Stat3, NF-κB, Smad3 and Smad7. Additionally, PCs exert dual activity of IL-10 and TGF-β secreted spontaneously by both peritoneal B cells and macrophages, which in turn enhance the induction of regulatory B cells and Macrophages in microenvironment of inflammation. Moreover, PCs can re-establish immunological tolerance in the OVA-immunized mice. Thus, our findings provide a new strategy for colitis therapy and could be of importance in additional exploration of other inflammation and autoimmune diseases therapy.
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