ArticleThe ISME journal2016
Lipid remodelling is a widespread strategy in marine heterotrophic bacteria upon phosphorus deficiency.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- The phospholipase PlcP mediates membrane lipid remodeling required for the intracellular survival of Burkholderia cenocepacia.The Journal of biological chemistry · 2026Article
- Phosphorus Acquisition Strategies Among Phytoplankton and Free-Living Bacterial Communities in the Baltic Proper.Environmental microbiology reports · 2026Article
- Exceptionally stable membrane lipid composition of the marine facultative anaerobe and piezotolerant 'Labilibaculum euxinus' under variable pressure and nutrients.FEMS microbiology ecology · 2026Article
- Dealing with phosphorus deficiency: contrasting strategies in marine phytoplankton and bacteria.ISME communications · 2026Article
- Phosphorus acquisition among planktonic microbial communities across a salinity gradient.ISME communications · 2026Article
- Cold-adaptive variations in the membrane lipid composition in polar species of the ciliateFrontiers in microbiology · 2026Article
- Structural basis and evolutionary pathways of glycerol-1-phosphate transport in marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids.Nature communications · 2025Article
- Decoding the genetic drivers of marine bacterial blooms through comparative genomics.Microbiome · 2025Article
- Virocell resource manipulation under nutrient limitation.mSystems · 2025Article
- The microbial phosphorus cycle in aquatic ecosystems.Nature reviews. Microbiology · 2025Review
- Daily microbial rhythms of the surface ocean interrupted by the new moon-a lipidomic study.ISME communications · 2025Article
- Nitrogen and sulfur for phosphorus: Lipidome adaptation of anaerobic sulfate-reducing bacteria in phosphorus-deprived conditions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Organic matter degradation in the deep, sulfidic waters of the Black Sea: insights into the ecophysiology of novel anaerobic bacteria.Microbiome · 2024Article
- A distinct, high-affinity, alkaline phosphatase facilitates occupation of P-depleted environments by marine picocyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- An update on Glycerophosphodiester Phosphodiesterases; From Bacteria to Human.The protein journal · 2024Review
- Autochthonous psychrophilic hydrocarbonoclastic bacteria and its ecological function in contaminated cold environments.Biodegradation · 2024Review
- Aminolipids in bacterial membranes and the natural environment.The ISME journal · 2024Review
- Deciphering the biosynthesis of a novel lipid in Mycobacterium tuberculosis expands the known roles of the nitroreductase superfamily.The Journal of biological chemistry · 2023Article
- Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon phosphorus (P) deficiency, marine phytoplankton reduce their requirements for P by replacing membrane phospholipids with alternative non-phosphorus lipids. It was very recently demonstrated that a SAR11 isolate also shares this capability when phosphate starved in culture. Yet, the extent to which this process occurs in other marine heterotrophic bacteria and in the natural environment is unknown. Here, we demonstrate that the substitution of membrane phospholipids for a variety of non-phosphorus lipids is a conserved response to P deficiency among phylogenetically diverse marine heterotrophic bacteria, including members of the Alphaproteobacteria and Flavobacteria. By deletion mutagenesis and complementation in the model marine bacterium Phaeobacter sp. MED193 and heterologous expression in recombinant Escherichia coli, we confirm the roles of a phospholipase C (PlcP) and a glycosyltransferase in lipid remodelling. Analyses of the Global Ocean Sampling and Tara Oceans metagenome data sets demonstrate that PlcP is particularly abundant in areas characterized by low phosphate concentrations. Furthermore, we show that lipid remodelling occurs seasonally and responds to changing nutrient conditions in natural microbial communities from the Mediterranean Sea. Together, our results point to the key role of lipid substitution as an adaptive strategy enabling heterotrophic bacteria to thrive in the vast P-depleted areas of the ocean.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.