ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2016
Entorhinal Cortex Thickness across the Human Lifespan.
Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Glymphatic function decline as a mediator of core memory-related brain structures atrophy in aging.Journal of translational internal medicine · 2025Article
- Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study.Frontiers in aging neuroscience · 2025Article
- Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Less spatial exploration is associated with poorer spatial memory in midlife adults.Frontiers in aging neuroscience · 2024Article
- The Overview of Cognitive Aging Models.Advances in experimental medicine and biology · 2023Article
- Quantitative and histologically validated measures of the entorhinal subfields inBrain communications · 2022Article
- Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years.Human brain mapping · 2022Article
- Brain aging mechanisms with mechanical manifestations.Mechanisms of ageing and development · 2021Review
- The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer's Disease Pathology.Life (Basel, Switzerland) · 2021Review
- Medial Temporal Lobe Subregional Atrophy in Aging and Alzheimer's Disease: A Longitudinal Study.Frontiers in aging neuroscience · 2021Article
- Contribution of iron and Aβ to age differences in entorhinal and hippocampal subfield volume.Neurology · 2020Article
- MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?Ageing research reviews · 2020Review
- Brain Morphometry Estimation: From Hours to Seconds Using Deep Learning.Frontiers in neurology · 2020Article
- Improving Accuracy of Brainstem MRI Volumetry: Effects of Age and Sex, and Normalization Strategies.Frontiers in neuroscience · 2020Article
- Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Longitudinal Mapping of Cortical Thickness Measurements: An Alzheimer's Disease Neuroimaging Initiative-Based Evaluation Study.Journal of Alzheimer's disease : JAD · 2019Article
- Article
- Predicting individual responses to the electroconvulsive therapy with hippocampal subfield volumes in major depression disorder.Scientific reports · 2018Article
- Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
background and purposeHuman entorhinal cortex (ERC) connects the temporal neocortex with hippocampus and is essential for memory retrieval and navigation. Markedly, there have been only few quantitative MRI works on the ERC geometric measurements in pediatric and adult healthy subjects across the lifespan. Here, we sought to fill this gap in knowledge by quantifying the ERC thickness in a very large cohort of subjects spanning 9 decades of life.
methodsUsing magnetic resonance imaging data from multiple centers (IXI, MMRR, NKI, OASIS combined with the NIH-Child Dev database and locally recruited healthy subjects), we analyzed the lifespan trajectory of ERC thickness in 1,660 healthy controls ranging from 2 to 94 years of age.
resultsThe ERC thickness increased with age, reached a peak at about 44 years, and then decreased with age. ERC thickness is hemispherically rightward-asymmetric with no gender differences. Mean ERC thickness was found to vary between 2.943 ± .438 mm and 3.525 ± .355 mm across different age populations. Also, more pronounced loss of the ERC thickness in healthy aging men was noticeable. DISCUSSION: Our report with high spatial resolution brain MRI data from 1,660 healthy controls provided important clues about ERC thickness across lifespan. We believe that our report will pave the way for the future studies investigating distinct neural pathologies related with cognitive dysfunctions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.