ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2015
Application of a free-energy-landscape approach to study tension-dependent bilayer tubulation mediated by curvature-inducing proteins.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology.Mechanobiology in medicine · 2024Article
- Free energy calculations for membrane morphological transformations and insights to physical biology and oncology.Methods in enzymology · 2024Article
- Crowding-induced membrane remodeling: Interplay of membrane tension, polymer density, architecture.Biophysical journal · 2022Article
- Data driven and biophysical insights into the regulation of trafficking vesicles by extracellular matrix stiffness.iScience · 2022Article
- Quantification of Curvature Sensing Behavior of Curvature-Inducing Proteins on Model Wavy Substrates.The Journal of membrane biology · 2022Article
- Biophysical Considerations in the Rational Design and Cellular Targeting of Flexible Polymeric Nanoparticles.Advanced materials interfaces · 2021Article
- Emergent membrane morphologies in relaxed and tense membranes in presence of reversible adhesive pinning interactions.Physical biology · 2019Article
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Article
- Epsin N-terminal Homology Domain (ENTH) Activity as a Function of Membrane Tension.The Journal of biological chemistry · 2016Article
- Curvature-undulation coupling as a basis for curvature sensing and generation in bilayer membranes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Probing lipid membrane bending mechanics using gold nanorod tracking.Physical review researchArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
We investigate the phenomenon of protein-induced tubulation of lipid bilayer membranes within a continuum framework using Monte Carlo simulations coupled with the Widom insertion technique to compute excess chemical potentials. Tubular morphologies are spontaneously formed when the density and the curvature-field strength of the membrane-bound proteins exceed their respective thresholds and this transition is marked by a sharp drop in the excess chemical potential. We find that the planar to tubular transition can be described by a micellar model and that the corresponding free-energy barrier increases with an increase in the curvature-field strength (i.e., of protein-membrane interactions) and also with an increase in membrane tension.
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