ArticleG3 (Bethesda, Md.)2015
On the Consequences of Purging and Linkage on Fitness and Genetic Diversity.
Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Homozygosity Accumulated Through Genetic Drift and Inbreeding Underpins High Mutation Load in an Endangered Beluga Whale Population.Molecular ecology · 2026Article
- Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.Genetics · 2026Article
- A Test of the Long-Term Efficiency of Genetic Rescue With Drosophila melanogaster.Molecular ecology · 2025Article
- A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads.Genetics · 2025Article
- A gene-based model of fitness and its implications for genetic variation: Genetic and inbreeding loads.bioRxiv : the preprint server for biology · 2025Article
- Estimation of Inbreeding Depression From Overdominant Loci Using Molecular Markers.Evolutionary applications · 2025Article
- Article
- Purging of deleterious burden in the endangered Iberian lynx.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic signatures of inbreeding in a critically endangered parrot, the kākāpō.G3 (Bethesda, Md.) · 2021Article
- Luzhong mutton sheep: inbreeding and selection signatures.Journal of animal science and technology · 2020Article
- Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster.Heredity · 2019Article
- Detection of genetic purging and predictive value of purging parameters estimated in pedigreed populations.Heredity · 2018Article
- Inferring Individual Inbreeding and Demographic History from Segments of Identity by Descent inGenetics · 2017Article
- Nucleotide diversity inflation as a genome-wide response to experimental lifespan extension in Drosophila melanogaster.BMC genomics · 2017Article
- Predictive Model and Software for Inbreeding-Purging Analysis of Pedigreed Populations.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the build up of coupling groups of (partially) recessive deleterious alleles. It also induces associative overdominance at neutral sites but rarely causes increased neutral genetic diversity in equilibrium populations. After a reduction in population size, linkage can cause some delay both for the expression of the inbreeding load and the corresponding purging. However, reasonable predictions can be obtained for the evolution of fitness under inbreeding and purging by using empirical estimates of the inbreeding depression rate. Purging selection against homozygotes for deleterious alleles affects the population's pedigree. Furthermore, it can slow the loss of genetic diversity compared to that expected from the variance of gametic contributions to the breeding group and even from pedigree inbreeding. Under some conditions, this can lead to a smaller loss of genetic diversity, even below that expected from population size in the absence of selection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.