Evidence map›Paper›PMID 26564900›Full record

ArticleGenetics2015

Genetics on the Fly: A Primer on the Drosophila Model System.

Karen G Hales, Christopher A Korey, Amanda M Larracuente, David M Roberts

Abstract read
In one paragraph

Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
161citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

161 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Identification ofFrontiers in immunology · 2026
    Review
  12. Ecology and Diversity of UrbanEcology and evolution · 2026
    Article
  13. microPublication biology · 2026
    Article
  14. Article
  15. Article
  16. Review
  17. Beyond Rodents: Alternative Animal Models in Colorectal Cancer Research.International journal of molecular sciences · 2025
    Review
  18. Article
  19. GαCell communication and signaling : CCS · 2025
    Article
  20. Review

101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Karen G HalesDepartment of Biology, Davidson College, Davidson North Carolina 28035 kahales@davidson.edu.
Christopher A KoreyBiology Department, College of Charleston, Charleston, South Carolina 29424.
Amanda M LarracuenteDepartment of Biology, University of Rochester, Rochester, New York 14627.
David M RobertsBiology Department, Franklin and Marshall College, Lancaster, Pennsylvania 17604.

Funding

A model system to study the tumor suppressor APC and its role in Wnt regulation.R15GM107796 · NIGMS · FRANKLIN AND MARSHALL COLLEGE · PI ROBERTS, DAVID · 2013 to 2017
$664k
Genetic control of mitochondrial aggregation in Drosophila spermatogenesisR15GM080689 · NIGMS · DAVIDSON COLLEGE · PI HALES, KAREN G · 2007 to 2012
$533k
NIGMS NIH HHS R15 GM080689NIGMS NIH HHS R15 GM107796
6 · The paper itself

Abstract

Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, evolutionary and population genetics, and other fields. With more tissue types and observable behaviors than in other short-generation model organisms, and with vast genome data available for many species within the genus, the fly's tractable complexity will continue to enable exciting opportunities to explore mechanisms of complex developmental programs, behaviors, and broader evolutionary questions. This primer describes the organism's natural history, the features of sequenced genomes within the genus, the wide range of available genetic tools and online resources, the types of biological questions Drosophila can help address, and historical milestones.

Indexed as

DrosophilaModels, BiologicalAnimalsModels, Geneticcomparative genomicsdevelopmentDrosophilamodel organism

Identifiers

PMID26564900
PMCPMC4649653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.