Trial reportJournal of optometry
Longitudinal changes in corneal curvature and its relationship to axial length in the Correction of Myopia Evaluation Trial (COMET) cohort.
Trial report in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Correlation between refractive errors and ocular biometric parameters in children and adolescents: a systematic review and meta-analysis.BMC ophthalmology · 2023Pooled it
- Interventions for myopia control in children: a living systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Interventions to slow progression of myopia in children.The Cochrane database of systematic reviews · 2020Pooled it
- Three-year cohort study on the predictive role of axial length-to-corneal radius ratio in the incidence and progression of myopia among Chinese schoolchildren.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Gender and Refractive Error Stratified Ocular Biometry Percentile Curves in Indian School Children.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Corneal power, axial length-to-corneal radius ratio, and myopia status prior to corneal refractive surgery: a cross-study analysis.International ophthalmology · 2026Article
- Robust and interpretable unit level causal inference in neural networks for pediatric myopia.NPJ digital medicine · 2026Article
- Article
- The correlation between myopia severity and stress-strain index (SSI) using the Corneal Visualization Scheimpflug Technology (Corvis ST).Scientific reports · 2025Article
- Optical and Visual Diet in Myopia.Investigative ophthalmology & visual science · 2025Review
- Associations between refraction and ocular biometry in Chinese preschoolers aged 3-6 years: a cross-sectional study in Shunyi, Beijing.BMJ open · 2025Article
- The Distribution of Ocular Normative Parameters in a Spanish School Population.Journal of clinical medicine · 2025Article
- Ocular Biometry Distribution and One-Year Growth in Eight-Year-Old Southern European Schoolchildren Under the CISViT Project.Children (Basel, Switzerland) · 2025Article
- Ocular biometric parameters in South-Indian children with myopia - A hospital-based retrospective descriptive analysis.Indian journal of ophthalmology · 2025Article
- Sleep Duration, Sleep Habits, and Social Jetlag From 4 to 6 years Their Impacts on Myopia Among School-Aged Children: The Ma'anshan Birth Cohort Study.Nature and science of sleep · 2025Article
- Cutoff Values of Noncycloplegic Spherical Equivalent Refraction for Myopia Detection in Southwestern Chinese Children.Journal of ophthalmology · 2025Article
- Refractive error after phacoemulsification combined with intraocular lens implantation in primary angle-closure glaucoma: a multifactorial analysis of biometric parameters and surgical strategies.Frontiers in cell and developmental biology · 2025Article
- The relationship between axial length and anterior segment biometry in high axial myopic Chinese students aged 7 to 18 years.Frontiers in medicine · 2025Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeTo describe longitudinal changes in corneal curvature (CC) and axial length (AL) over 14 years, and to explore the relationship between AL and CC, and the axial length/corneal radius (AL/CR) ratio.
methodsIn total 469, 6 to <12-year-old, children were enrolled in COMET. Measurements of refractive error, CC (D), CR (mm), and ocular component dimensions including AL were gathered annually. Linear mixed models were used to evaluate longitudinal changes adjusting for covariates (gender, ethnicity, lens type, baseline age and baseline refraction). The Pearson correlation coefficient between AL and CC was computed at each visit.
resultsThere was a slight but significant (p<0.0001) flattening in CC over 14 years. At all visits females had significantly steeper CC than males (overall difference=0.53 D, p<0.0001). Caucasians had the steepest CC, and Hispanics the flattest (p=0.001). The correlation between AL and CC was -0.70 (p<0.0001) at baseline (mean age=9.3 years) and decreased to -0.53 (p<0.0001) at the 14-year visit (mean age=24.1 years). The average AL/CR ratio was 3.15 at baseline and increased to 3.31 at the 14-year visit. The correlation between the magnitude of myopia and AL/CR ratio was significantly higher (p<0.0001) at each visit than the correlation between myopia and AL alone.
conclusionsDifferences in average corneal curvature by age, gender, and ethnicity observed in early childhood remain consistent as myopia progresses and stabilizes. This study also demonstrates increases in the AL/CR ratio as myopia progresses and then stabilizes, supporting observations from previous cross-sectional data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.