Evidence map›Paper›PMID 26564200›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2015

Phenotypes of orthostatic blood pressure behaviour and association with visual acuity.

Bláithín Ní Bhuachalla, Christine A McGarrigle, Kwadwo Owusu Akuffo, Tunde Peto, Stephen Beatty, Rose Anne Kenny

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Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Bláithín Ní BhuachallaDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Old Stone Building, James's Street, Dublin 8, Ireland. nibhuacb@tcd.ie.
Christine A McGarrigleThe Irish Longitudinal Study on Ageing (TILDA), Trinity College Dublin, College Green, Lincoln Gate, Dublin 2, Ireland. Christine.McGarrigle@tcd.ie.
Kwadwo Owusu AkuffoMacular Pigment Research Group, Vision Research Centre Carriganore House, Waterford Institute of Technology, Waterford, Ireland. kakuffo@wit.ie.
Tunde PetoDepartment of Research and Development, National Institute of Health Research Biomedical Research Centre at Moorfields Eye Hospital National Health Service Foundation Trust and UCL Institute of Ophthalmology, London, UK. Tunde.Peto@moorfields.nhs.uk.
Stephen BeattyMacular Pigment Research Group, Vision Research Centre Carriganore House, Waterford Institute of Technology, Waterford, Ireland. sbeatty@wit.ie.
Rose Anne KennyDepartment of Medical Gerontology, School of Medicine, Trinity College Dublin, Trinity Centre for Health Sciences, St James's Hospital, Old Stone Building, James's Street, Dublin 8, Ireland. rkenny@tcd.ie.
Trinity College Dublin · IEWaterford Institute of Technology · IENational Health Service · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundManifestations of neurocardiovascular instability (NCVI), including orthostatic hypotension (OH) orthostatic hypertension (OHTN) and impaired blood pressure variability (BPV), have been associated with cardiovascular (CV) events. The eye is highly vascular and we propose an ideal target end organ to investigate pathological implications of NCVI.

objectiveTo identify and define clinically applicable phenotypes of orthostatic blood pressure (BP) behaviour, analogous to OH, OHTN, and orthostatic BPV and to investigate their relationship to vision.

methodsWave one data from the Irish Longitudinal Study on Ageing (TILDA) were used. Orthostatic BP (OBP) phenotypes were identified and defined from beat-to-beat BP data, measured by digital photoplethysmography during an active stand (AS) lasting 110 s (s). Visual acuity (VA) was assessed using the Early Treatment Diabetic Retinopathy Study (EDTRS) LogMAR chart. The relationship between OBP phenotypes and VA in 4355 adults aged ≥50 years was investigated through multivariate linear regression models.

resultsThere was a wide fluctuation in the prevalence of OH and OHTN up to 20 s after standing. After 30 s, four distinct OBP phenotypes were identified: in 70 % BP stabilised to within 20/10 mmHg of baseline BP, 4 % had persistent OH, 2 % had persistent OHTN and 25 % had exaggerated orthostatic blood pressure variability BPV. Systolic BPV was associated with worse VA (P = 0.02) as was diastolic BPV (P = 0.03), following adjustment for demographics, health behaviours, self-report eye diseases and diabetes, uncorrected refractive error, objective hypertension and antihypertensives.

conclusionsThe hypothesis that NCVI may independently modulate CV risk is supported the independent association of exaggerated BPV and worse VA.

Indexed as

PhenotypeAgedAgingBlood PressureCross-Sectional StudiesFemaleHumansHypotension, OrthostaticIrelandLongitudinal StudiesMaleMiddle AgedVisual AcuityBlood pressure variabilityEnd-organ damageEyeOrthostatic hypertensionOrthostatic hypotensionVisual acuity

Identifiers

PMID26564200
OpenAlexW2283915135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.