SynthesisDiabetologia2016
Vaccinations and childhood type 1 diabetes mellitus: a meta-analysis of observational studies.
Synthesis in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature.Frontiers in endocrinology · 2022Pooled it
- Caring for children and adolescents with type 1 diabetes mellitus: Italian Society for Pediatric Endocrinology and Diabetology (ISPED) statements during COVID-19 pandemia.Diabetes research and clinical practice · 2020Guideline
- Respiratory infections and type 1 diabetes: Potential roles in pathogenesis.Reviews in medical virology · 2023Review
- New-onset fulminant type 1 diabetes after severe acute respiratory syndrome coronavirus 2 vaccination: A case report.Journal of diabetes investigation · 2022Article
- Enteroviruses and Type 1 Diabetes: Multiple Mechanisms and Factors?Annual review of medicine · 2022Review
- Novel artful applications of vaccines at the horizon.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Article
- Environmental Triggering of Type 1 Diabetes Autoimmunity.Frontiers in endocrinology · 2022Review
- Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review.Frontiers in endocrinology · 2022Review
- The Childhood Vaccination Schedule and the Lack of Association With Type 1 Diabetes.Pediatrics · 2021Article
- Review
- Childhood Vaccinations and Type 1 Diabetes.Frontiers in immunology · 2021Review
- Environmental Determinants of Type 1 Diabetes: From Association to Proving Causality.Frontiers in immunology · 2021Review
- Type 1 diabetes-early life origins and changing epidemiology.The lancet. Diabetes & endocrinology · 2020Review
- The Challenges of Identifying Environmental Determinants of Type 1 Diabetes: In Search of the Holy Grail.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Vaccine Safety: Myths and Misinformation.Frontiers in microbiology · 2020Review
- Vaccine Hesitancy and Illness Perceptions: Comparing Parents of Children with Autism Spectrum Disorder to other Parent Groups.Children's health care : journal of the Association for the Care of Children's Health · 2020Article
- Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus-A Narrative Review.Molecules (Basel, Switzerland) · 2018Review
- Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children.Diabetologia · 2018Article
- Environmental risk factors for type 1 diabetes.Lancet (London, England) · 2016Review
- Association between exanthematous diseases and earlier age at Type 1 diabetes diagnosis: a Brazilian cohort study.Jornal de pediatriaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
aims/hypothesisThe aim of this study was to investigate the association between routine vaccinations and the risk of childhood type 1 diabetes mellitus by systematically reviewing the published literature and performing meta-analyses where possible.
methodsA comprehensive literature search was performed of MEDLINE and EMBASE to identify all studies that compared vaccination rates in children who subsequently developed type 1 diabetes mellitus and in control children. ORs and 95% CIs were obtained from published reports or derived from individual patient data and then combined using a random effects meta-analysis.
resultsIn total, 23 studies investigating 16 vaccinations met the inclusion criteria. Eleven of these contributed to meta-analyses which included data from between 359 and 11,828 childhood diabetes cases. Overall, there was no evidence to suggest an association between any of the childhood vaccinations investigated and type 1 diabetes mellitus. The pooled ORs ranged from 0.58 (95% CI 0.24, 1.40) for the measles, mumps and rubella (MMR) vaccination in five studies up to 1.04 (95% CI 0.94, 1.14) for the haemophilus influenza B (HiB) vaccination in 11 studies. Significant heterogeneity was present in most of the pooled analyses, but was markedly reduced when analyses were restricted to study reports with high methodology quality scores. Neither this restriction by quality nor the original authors' adjustments for potential confounding made a substantial difference to the pooled ORs. CONCLUSIONS/
interpretationThis study provides no evidence of an association between routine vaccinations and childhood type 1 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.