ArticleBiomechanics and modeling in mechanobiology2016
Multiscale modelling of solid tumour growth: the effect of collagen micromechanics.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Novel Decomposition-Based Growth Model for Simulating Stress-Modulated Spinal Growth.International journal for numerical methods in biomedical engineering · 2026Article
- 3D Microscale Mechanical Simulations of Hydrogel Coated Electrospun Meshes.bioRxiv : the preprint server for biology · 2026Article
- A multiscale discrete fiber model of failure in heterogeneous tissues: Applications to remodeled cerebral aneurysms.Journal of biomechanics · 2025Article
- Spatial Configurations of 3D Extracellular Matrix Collagen Density and Anisotropy Simultaneously Guide Angiogenesis.PLoS computational biology · 2023Article
- Review
- Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks - Implications for Tumor Growth.Scientific reports · 2019Article
- A quantitativeInterface focus · 2019Article
- In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability.PLoS computational biology · 2018Article
- The Solid Mechanics of Cancer and Strategies for Improved Therapy.Journal of biomechanical engineering · 2017Review
- Multiscale biphasic modelling of peritumoural collagen microstructure: The effect of tumour growth on permeability and fluid flow.PloS one · 2017Article
- A Validated Multiscale In-Silico Model for Mechano-sensitive Tumour Angiogenesis and Growth.PLoS computational biology · 2017Article
- Production of a Self-Aligned Scaffold, Free of Exogenous Material, from Dermal Fibroblasts Using the Self-Assembly Technique.Dermatology research and practice · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre-fibre and tumour-fibre interactions. We hypothesise that such a model, which provides a purely mechanical description of tumour-host interactions, can be used to explain experimental observations of the effect of collagen micromechanics on solid tumour growth. The model was specified to mouse tumour data, and numerical simulations were performed. The multiscale model produced lower stresses than an equivalent continuum-like approach, due to a more realistic remodelling of the collagen microstructure. Furthermore, solid tumour growth was found to cause a passive mechanical realignment of fibres at the tumour boundary from a random to a circumferential orientation. This is in accordance with experimental observations, thus demonstrating that such a response can be explained as purely mechanical. Finally, peritumoural fibre network anisotropy was found to produce anisotropic tumour morphology. The dependency of tumour morphology on the peritumoural microstructure was reduced by adding a load-bearing non-collagenous component to the fibre network constitutive equation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.