ReviewAmerican journal of hypertension2016
Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future.
Review in American journal of hypertension, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Pooled it
- Life's Essential 8, genetic susceptibility, and risk of cognitive impairment: results from an elder population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Article
- Late-Life Blood Pressure and Cerebral Amyloid Angiopathy: Findings from the U.S. National Alzheimer's Coordinating Center Uniform Dataset.Neurology international · 2024Article
- Charting Alzheimer's Disease and Dementia: Epidemiological Insights, Risk Factors and Prevention Pathways.Journal of clinical medicine · 2024Review
- Cognitive Functioning Among Community-dwelling Older Adults in Rural Population of Lucknow and Its Association with Comorbidities.Indian journal of psychological medicine · 2024Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Association of Physiological Performance, Physical Fitness, and Academic Achievement in Secondary School Students.Children (Basel, Switzerland) · 2024Article
- Investigating the effect of hypertension on vascular cognitive impairment by using the resting-state functional connectome.Scientific reports · 2024Article
- Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing.Nutrients · 2023Review
- Integrating transcriptomics and metabolomics to analyze the mechanism of hypertension-induced hippocampal injury.Frontiers in molecular neuroscience · 2023Article
- Cardiovascular reactions to acute psychological stress and academic achievement.Psychophysiology · 2022Article
- Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
- Association between blood pressure control status, visit-to-visit blood pressure variability, and cognitive function in elderly Chinese: A nationwide study.Frontiers in public health · 2022Article
- Hypertensive Aspects of Cardiometabolic Disorders Are Associated with Lower Brain Microstructure, Perfusion, and Cognition.Journal of Alzheimer's disease : JAD · 2022Article
- Threshold effect of plasma total homocysteine levels on cognitive function among hypertensive patients in China: A cross-sectional study.Frontiers in neurology · 2022Article
- Risk Factors Affecting Cognitive Impairment of the Elderly Aged 65 and Over: A Cross-Sectional Study.Frontiers in aging neuroscience · 2022Article
- Cerebrovascular Function, Vascular Risk, and Lifestyle Patterns in Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2022Article
- Burden and correlates of cognitive impairment among hypertensive patients in Tanzania: a cross-sectional study.BMC neurology · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
This review summarizes evidence from studies of blood pressure and dementia-related biomarkers into our understanding of cognitive health and highlights the challenges facing studies, particularly randomized trials, of hypertension and cognition. Several lines of research suggest that elevated blood pressure, especially at midlife, is associated with cognitive decline and dementia and that treatment of hypertension could prevent these conditions. Further, studies of hypertension and brain structure show that blood pressure is associated with several forms of small vessel disease that can result in vascular dementia or interact with Alzheimer's pathology to lower the pathologic threshold at which Alzheimer's signs and symptoms manifest. In addition, recent studies of hypertension and Alzheimer's biomarkers show that elevated blood pressure and pulse pressure are associated with the extent of brain beta amyloid (Aβ) deposition and altered cerebral spinal fluid profiles of Aβ and tau indicative of Alzheimer's pathology. However, in spite of strong evidence of biological mechanisms, results from randomized trials of antihypertensive therapy for the prevention of cardiovascular or cerebrovascular disease that include cognitive endpoints do not strongly support the observational evidence that treatment of hypertension should be better for cognition. We propose that future clinical trials should consider including dementia biomarkers and assess genetic and cardiometabolic risk factors that have been associated with progression of the underlying disease pathology to help bridge these gaps.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.