ArticleInternational journal of obesity (2005)2016
Body fat mass and the proportion of very large adipocytes in pregnant women are associated with gestational insulin resistance.
Article in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Fat Cell Size: Measurement Methods, Pathophysiological Origins, and Relationships With Metabolic Dysregulations.Endocrine reviews · 2022Pooled it
- Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018Pooled it
- Trial
- Associations of body composition and physical fitness with gestational diabetes and cardiovascular health in pregnancy: Results from the HealthyMoms trial.Nutrition & diabetes · 2021Trial
- Deep subcutaneous adipose tissue is the most metabolically active adipose depot in pregnant women- a preliminary study by ex-vivo analysis.BMC pregnancy and childbirth · 2025Article
- Structural and Metabolic Changes in Pregnant Rat Uterine and Adipose Tissue Induced by a High-Fat High-Sugar Diet.Biomolecules · 2025Article
- IL-27 alleviates high-fat diet-induced obesity and metabolic disorders by inhibiting adipogenesis via activating HDAC6.Communications biology · 2025Article
- Article
- Infant body composition relationship to maternal adipokines and fat mass: the PONCH study.Pediatric research · 2021Article
- Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction.Obesity surgery · 2020Review
- PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans.Science translational medicine · 2020Article
- Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes.International journal of molecular sciences · 2020Review
- Longitudinal changes in adipokines and free leptin index during and after pregnancy in women with obesity.International journal of obesity (2005) · 2020Article
- The relationship between sex steroids, insulin resistance and body compositions in obese women: A case-control study.Journal of medical biochemistry · 2020Article
- Maternal obesity and gestational diabetes mellitus affect body composition through infancy: the PONCH study.Pediatric research · 2019Article
- Review
- Free lipid and computerized determination of adipocyte size.Adipocyte · 2018Article
- Avoiding excessive pregnancy weight gain to obtain better pregnancy outcomes in Taiwan.Medicine · 2018Article
- Maternal adipokines and insulin as biomarkers of pregnancies complicated by overweight and obesity.Diabetology & metabolic syndrome · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesPregnancy is accompanied by fat gain and insulin resistance. Changes in adipose tissue morphology and function during pregnancy and factors contributing to gestational insulin resistance are incompletely known. We sought to characterize adipose tissue in trimesters 1 and 3 (T1/T3) in normal weight (NW) and obese pregnant women, and identify adipose tissue-related factors associated with gestational insulin resistance. SUBJECTS/
methodsTwenty-two NW and 11 obese women were recruited early in pregnancy for the Pregnancy Obesity Nutrition and Child Health study. Examinations and sampling of blood and abdominal adipose tissue were performed longitudinally in T1/T3 to determine fat mass (air-displacement plethysmography); insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR); size, number and lipolytic activity of adipocytes; and adipokine release and density of immune cells and blood vessels in adipose tissue.
resultsFat mass and HOMA-IR increased similarly between T1 and T3 in the groups; all remained normoglycemic. Adipocyte size increased in NW women. Adipocyte number was not influenced, but proportions of small and large adipocytes changed oppositely in the groups. Lipolytic activity and circulating adipocyte fatty acid-binding protein increased in both groups. Adiponectin release was reduced in NW women. Fat mass and the proportion of very large adipocytes were most strongly associated with T3 HOMA-IR by multivariable linear regression (R(2)=0.751, P<0.001).
conclusionsDuring pregnancy, adipose tissue morphology and function change comprehensively. NW women accumulated fat in existing adipocytes, accompanied by reduced adiponectin release. In comparison with the NW group, obese women had signs of adipocyte recruitment and maintained adiponectin levels. Body fat and large adipocytes may contribute significantly to gestational insulin resistance.
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