ArticleThe journal of allergy and clinical immunology. In practice
Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 60 citations in OpenAlex.
- A Randomized, Double-Blind, Placebo-Controlled Trial of Escitalopram in Patients with Asthma and Major Depressive Disorder.The journal of allergy and clinical immunology. In practiceTrial
- Article
- Depression in children with asthma: Testing a cholinergically mediated "endotype".The journal of allergy and clinical immunology. Global · 2026Article
- Depression increases the risk of contracting genital herpes and genital wart in U.S. adults: A cross-sectional analysis.Medicine · 2025Article
- Effects of chronic allergic lung inflammation on gut microbiota and depression-like behavior in mice.Exploration of asthma & allergy · 2025Article
- The effects of violence and related stress on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Association of composite dietary antioxidant index with depression and all-cause mortality in middle-aged and elderly population.Scientific reports · 2024Article
- Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024Review
- Post Hoc Analysis of Lung Function Improvement and Patient-Reported Outcomes With Revefenacin in Adults With Moderate-to-Very Severe COPD and Comorbid Anxiety or Depression.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
- The interaction effects between depression and sleep status on asthma: a national cross-sectional study.Frontiers in psychiatry · 2024Article
- Management of comorbidities in difficult and severe asthma.Breathe (Sheffield, England) · 2023Review
- Anxiety in adults with asthma during the coronavirus disease 2019 pandemic: a Canadian perspective.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Depressive symptoms are related to asthma control but not self-management among rural adolescents.Frontiers in allergy · 2023Article
- Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank.The European respiratory journal · 2022Article
- Asthma interactions between obesity and other risk factors.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Review
- The Management of Extrapulmonary Comorbidities and Treatable Traits; Obesity, Physical Inactivity, Anxiety, and Depression, in Adults With Asthma.Frontiers in allergy · 2021Review
- Accountable Care Organizations and Preventable Hospitalizations Among Patients With Depression.American journal of preventive medicine · 2020Article
- Structural and Social Determinants of Health in Asthma in Developed Economies: a Scoping Review of Literature Published Between 2014 and 2019.Current allergy and asthma reports · 2020Article
- Eliminating health disparities in asthma: Are we at the end of the beginning?Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Psychosocial risk factors and asthma among adults in Puerto Rico.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLittle is known about the relation between 2 common comorbidities (depression and anxiety) and asthma or bronchodilator response (BDR).
objectiveTo examine the association between depressive symptoms and asthma or BDR in US adults.
methodsCross-sectional study of 20,272 adults aged 20 to 79 years from the 2007-2012 National Health and Nutrition Examination Survey. Depressive symptoms were measured using the 9-item Patient Health Questionnaire, and classified as none to minimal, mild, moderate, moderately severe, and severe. Major depression (comprising moderately severe to severe symptoms) was defined as a 9-item Patient Health Questionnaire score of 15 or more. Anxiety was defined as 5 or more days feeling anxious in the previous month. Current asthma was defined as having been diagnosed with asthma by a doctor or health professional and 1 or more asthma attack in the previous year. BDR (as percentage of baseline FEV1) was measured in 1356 participants with FEV1/forced vital capacity of less than 0.70 and/or FEV1 less than 70% of predicted. Logistic or linear regression was used for the multivariable analysis.
resultsDepressive symptoms were significantly and linearly associated with asthma, independently of anxiety symptoms. Subjects with major depression had 3.4 times higher odds of asthma than did those with minimal or no depressive symptoms (95% CI, 2.6-4.5; P < .01). Among adults with asthma, major depression was associated with a 4.2% reduction in BDR (95% CI, -7.5% to -0.8%; P = .02). Major depression was not associated with BDR among adults without asthma. Anxiety was not associated with asthma or BDR.
conclusionsDepressive symptoms are associated with asthma in adults, independently of anxiety symptoms. Major depression is associated with reduced BDR in adults with asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.