Evidence map›Paper›PMID 26563668›Full record

ArticleThe journal of allergy and clinical immunology. In practice

International Consensus Document (ICON): Common Variable Immunodeficiency Disorders.

Francisco A Bonilla, Isil Barlan, Helen Chapel, Beatriz T Costa-Carvalho, Charlotte Cunningham-Rundles, M Teresa de la Morena, Francisco J Espinosa-Rosales, Lennart Hammarström, Shigeaki Nonoyama, Isabella Quinti and 3 more

Registry-linked trialAbstract readConsensus Statement
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06089122 (Efficacy, Safety, and Pharmacokinetics of Shu Yang IVIG in Patients With Primary Immunodeficiency), which is not on this map. Cited by 426 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
426citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06089122 phase3unknown statusnot on this map

Efficacy, Safety, and Pharmacokinetics of Shu Yang IVIG in Patients With Primary Immunodeficiency

TypeinterventionalSponsorAzidus BrasilRan2024 to 2025Enrolled50ConditionsPrimary Immunodeficiency DiseaseArmsIVIG
3 · Its place in the literature

Who cites it

426 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Elevated CD21Journal of clinical immunology · 2022
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. 25-Hydroxyvitamin D Sufficiency Is Associated With Reduced Atelectasis in Common Variable Immunodeficiency: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  9. Article
  10. Article
  11. Elevated IL-10 is Linked With the Expansion of T-betJournal of clinical immunology · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

366 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Francisco A BonillaBoston Children's Hospital and Harvard Medical School, Boston, Mass. Electronic address: Francisco.bonilla@childrens.harvard.edu.
Isil BarlanMarmara University Pendik Education and Research Hospital, Istanbul, Turkey.
Helen ChapelJohn Radcliffe Hospital and University of Oxford, Oxford, United Kingdom.
Beatriz T Costa-CarvalhoFederal University of São Paulo, São Paulo, Brazil.
Charlotte Cunningham-RundlesMount Sinai Medical Center, New York, NY.
M Teresa de la MorenaChildren's Medical Center and University of Texas Southwestern Medical Center, Dallas, Texas.
Francisco J Espinosa-RosalesInstituto Nacional de Pediatría, Mexico City, Mexico.
Lennart HammarströmKarolinska Institute, Stockholm, Sweden.
Shigeaki NonoyamaNational Defense Medical College, Saitama, Japan.
Isabella QuintiSapienza University, Rome, Italy.
John M RoutesChildren's Hospital of Wisconsin and Medical College of Wisconsin, Milwaukee, Wis.
Mimi L K TangRoyal Children's Hospital and Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia.
Klaus WarnatzUniversity Medical Center Freiburg, Freiburg, Germany.

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)U24AI086037 · NIAID · IMMUNE DEFICIENCY FOUNDATION · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2010 to 2019
$6.5M
TARGETING PRIMARY IMMUNODEFICIENCY AMONG MINORITIESR18AI048693 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2000 to 2016
$6.2M
Primary Immunne Deficiency Consortium ConferenceR13AI065141 · NIAID · CLINICAL IMMUNOLOGY SOCIETY · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2005 to 2005
$43k
NIAID NIH HHS P01 AI061093NIAID NIH HHS R13 AI065141NIAID NIH HHS R18 AI048693NIAID NIH HHS U24 AI086037
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgammaglobulinemiaAge FactorsAlgorithmsB-LymphocytesCommon Variable ImmunodeficiencyDiagnosis, DifferentialHumansImmunophenotypingInternational Cooperation

Identifiers

PMID26563668
PMCPMC4869529

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.