ArticleAngewandte Chemie (International ed. in English)2016
Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
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- Discovery of a dimeric isopimarane derivative by reexploring a labdane-related diterpenoid biosynthetic gene cluster in Aspergillus nidulans.Microbial cell factories · 2026Article
- Ethyl methanesulfonate mutagenesis in fungi: genetic mechanisms, applications, and implications for agricultural biotechnology.Archives of microbiology · 2026Review
- Genetic Dereplication of MultipleJournal of natural products · 2026Article
- A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl-Aryl Ether Formation in the Biosynthesis of Emestrin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Biosynthesis of the α-D-mannosidase inhibitor (-)-Swainsonine.Nature chemical biology · 2026Article
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- Unveiling nonribosomal peptide synthetases from the ergot fungusActa pharmaceutica Sinica. B · 2025Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Considerations for Domestication of Novel Strains of Filamentous Fungi.ACS synthetic biology · 2025Review
- Biosynthesis of a Novel Diketopiperazine Aspkyncin Incorporating a Kynurenine Unit fromJournal of fungi (Basel, Switzerland) · 2025Article
- Expression of a Colletotrichum polyketide synthase gene in Aspergillus nidulans leads to unexpected conjugates with a host metabolite.Archives of microbiology · 2025Article
- Biosynthesis of the Antifungal Polyhydroxy-Polyketide Acrophialocinol.Organic letters · 2025Article
- Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Transcription Factor Engineering inJournal of natural products · 2024Article
- Biosynthesis of iron-chelating terramides A-C and their role in Aspergillus terreus infection.Communications chemistry · 2024Article
16 more citing papers are in PubMed but not listed here.
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8 authors.
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Abstract
To reduce the secondary metabolite background in Aspergillus nidulans and minimize the rediscovery of compounds and pathway intermediates, we created a "genetic dereplication" strain in which we deleted eight of the most highly expressed secondary metabolite gene clusters (more than 244,000 base pairs deleted in total). This strain allowed us to discover a novel compound that we designate aspercryptin and to propose a biosynthetic pathway for the compound. Interestingly, aspercryptin is formed from compounds produced by two separate gene clusters, one of which makes the well-known product cichorine. This raises the exciting possibility that fungi use differential regulation of expression of secondary metabolite gene clusters to increase the diversity of metabolites they produce.
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