ArticleTransplant international : official journal of the European Society for Organ Transplantation2016
Clinical and economic consequences of first-year urinary tract infections, sepsis, and pneumonia in contemporary kidney transplantation practice.
Article in Transplant international : official journal of the European Society for Organ Transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The value of procalcitonin and urinary NGAL in the prediction of acute pyelonephritis and kidney scarring in pediatric patients with a history of febrile urinary tract infection: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- Gut Colonisation and Multidrug-Resistant Urinary Tract Infections in Hospitalised Kidney Transplant Recipients: A Single-Centre Retrospective Study.Antibiotics (Basel, Switzerland) · 2026Article
- Etiology, incidence and clinical manifestations of urinary tract infections in evolving population of kidney transplant recipients - a single center 10-year retrospective analysis.Frontiers in cellular and infection microbiology · 2026Article
- Clinical Impact of Treating Versus Not Treating Asymptomatic Bacteriuria/Candiduria in the First Two Months After Kidney Transplantation.Antibiotics (Basel, Switzerland) · 2025Article
- Clinical and financial impacts of nursing education programs on recurrent urinary tract infections after kidney transplant: a cohort study.BMC nephrology · 2025Article
- A five-year retrospective study focused on urinary tract infections in kidney transplant recipients in the current era of immunosuppression.Frontiers in medicine · 2025Article
- Urinary Tract Infections in Kidney Transplant Patients: An Open Challenge-Update on Epidemiology, Risk Factors and Management.Microorganisms · 2024Review
- Body fat predicts urinary tract infection in kidney transplant recipients: a prospective cohort study.Journal of nephrology · 2024Article
- Acidic Urine pH and Clinical Outcome of Lower Urinary Tract Infection in Kidney Transplant Recipients Treated with Ciprofloxacin and Fosfomycin.Antibiotics (Basel, Switzerland) · 2024Article
- Assessing the quality of antimicrobial prescribing in solid organ transplant recipients: a new frontier in antimicrobial stewardship.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Age at Mortality in Patients with Type 2 Diabetes Who Underwent Kidney Transplantation: An Analysis of Data from the Korean National Health Insurance and Statistical Information Service, 2006 to 2018.Journal of clinical medicine · 2023Article
- Article
- Application of Various Techniques to Gain Insights Into the Complex Urinary Tract Microbial Communities of Renal Transplant Recipients.Transplantation direct · 2023Article
- Asymptomatic Bacteriuria in Kidney Transplant Recipients-A Narrative Review.Medicina (Kaunas, Lithuania) · 2023Review
- A Contemporary Evaluation of Urological Outcomes After Renal Transplantation.Urology practice · 2023Article
- Impact of different urinary tract infection phenotypes within the first year post-transplant on renal allograft outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Kidney Transplantation, Immunosuppression and the Risk of Fracture: Clinical and Economic Implications.Kidney medicine · 2022Article
- Long-Term Infectious Complications of Kidney Transplantation.Clinical journal of the American Society of Nephrology : CJASN · 2022Review
- Risk factors for urinary tract infection in kidney transplantation from brain death donor and its role in graft function.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Impact of Treating Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Prospective Cohort Study.Antibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
We examined United States Renal Data System registry records for Medicare-insured kidney transplant recipients in 2000-2011 to study the clinical and cost impacts of urinary tract infections (UTI), pneumonia, and sepsis in the first year post-transplant among a contemporary, national cohort. Infections were identified by billing diagnostic codes. Among 60 702 recipients, 45% experienced at least one study infection in the first year post-transplant, including UTI in 32%, pneumonia in 13%, and sepsis in 12%. Older recipient age, female sex, diabetic kidney failure, nonstandard criteria organs, sirolimus-based immunosuppression, and steroids at discharge were associated with increased risk of first-year infections. By time-varying, multivariate Cox regression, all study infections predicted increased first-year mortality, ranging from 41% (aHR 1.41, 95% CI 1.25-1.56) for UTI alone, 6- to 12-fold risk for pneumonia or sepsis alone, to 34-fold risk (aHR 34.38, 95% CI 30.35-38.95) for those with all three infections. Infections also significantly increased first-year costs, from $17 691 (standard error (SE) $591) marginal cost increase for UTI alone, to approximately $40 000-$50 000 (SE $1054-1238) for pneumonia or sepsis alone, to $134 773 (SE $1876) for those with UTI, pneumonia, and sepsis. Clinical and economic impacts persisted in years 2-3 post-transplant. Early infections reflect important targets for management protocols to improve post-transplant outcomes and reduce costs of care.
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