ArticleMolecular genetics and genomics : MGG2016
Evolution of the KCS gene family in plants: the history of gene duplication, sub/neofunctionalization and redundancy.
Article in Molecular genetics and genomics : MGG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Seed Priming with Gibberellic Acid Enhances Drought Tolerance in Sweet Sorghum by Modulating Cuticular Wax and Cutin Composition.Plants (Basel, Switzerland) · 2026Article
- Genome-wide analysis of KCS gene family in sunflower reveals the involvement of HaKCS1-1 in wax biosynthesis and drought resistance.BMC plant biology · 2026Article
- Article
- Telomere-to-telomere assemblies of chromosome 10 reveal complex adaptive variation of 3-ketoacyl-CoA-synthases inForestry research · 2026Article
- Structural basis of VLCFA chain-length determination by the KCS6-CER2 complex in plants.Science advances · 2025Article
- Molecular basis of very-long-chain fatty acid elongation by the CER6-GL2 enzyme complex in plant wax biosynthesis.Science advances · 2025Article
- Genetic diversity and adaptive evolutionary history of Sapindus in China: insights from whole-genome resequencing of 100 representative individuals.Plant biotechnology journal · 2025Article
- Genome-wide analysis of the KCS gene family in Medicago truncatula and their expression profile under various abiotic stress.Scientific reports · 2025Article
- The Function of TwoPlants (Basel, Switzerland) · 2025Article
- Phylogenomic and synteny analysis of BAHD and SCP/SCPL gene families reveal their evolutionary histories in plant specialized metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Identification of candidate genes and genomic prediction of soybean fatty acid components in two soybean populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Isolation and Functional Characterization of a Constitutive Promoter in Upland Cotton (International journal of molecular sciences · 2024Article
- An ancestral role for 3-KETOACYL-COA SYNTHASE3 as a negative regulator of plant cuticular wax synthesis.The Plant cell · 2023Article
- Hello darkness, my old friend: 3-KETOACYL-COENZYME A SYNTHASE4 is a branch point in the regulation of triacylglycerol synthesis in Arabidopsis thaliana.The Plant cell · 2023Article
- Genome-Wide Investigation and Functional Analysis Reveal ThatFoods (Basel, Switzerland) · 2023Article
- Genome-Scale Analysis of the Grapevine KCS Genes Reveals Its Potential Role in Male Sterility.International journal of molecular sciences · 2023Article
- Genome-wide identification and expression analysis of theFrontiers in plant science · 2023Article
- Genome-wide identification and expression analysis of 3-ketoacyl-CoA synthase gene family in rice (Frontiers in plant science · 2023Article
- Epicuticular wax accumulation and regulation of wax pathway gene expression during bioenergy Sorghum stem development.Frontiers in plant science · 2023Article
- Modifying the yeast very long chain fatty acid biosynthetic machinery by the expression of plant 3-ketoacyl CoA synthase isozymes.Scientific reports · 2022Article
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6 authors.
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Abstract
Very long-chain fatty acids (VLCFAs) play an important role in the survival and development of plants, and VLCFA synthesis is regulated by β-ketoacyl-CoA synthases (KCSs), which catalyze the condensation of an acyl-CoA with malonyl-CoA. Here, we present a genome-wide survey of the genes encoding these enzymes, KCS genes, in 28 species (26 genomes and two transcriptomes), which represents a large phylogenetic scale, and also reconstruct the evolutionary history of this gene family. KCS genes were initially single-copy genes in the green plant lineage; duplication resulted in five ancestral copies in land plants, forming five fundamental monophyletic groups in the phylogenetic tree. Subsequently, KCS genes duplicated to generate 11 genes of angiosperm origin, expanding up to 20-30 members in further-diverged angiosperm species. During this process, tandem duplications had only a small contribution, whereas polyploidy events and large-scale segmental duplications appear to be the main driving force. Accompanying this expansion were variations that led to the sub- and neofunctionalization of different members, resulting in specificity that is likely determined by the 3-D protein structure. Novel functions involved in other physiological processes emerged as well, though redundancy is also observed, largely among recent duplications. Conserved sites and variable sites of KCS proteins are also identified by statistical analysis. The variable sites are likely to be involved in the emergence of product specificity and catalytic power, and conserved sites are possibly responsible for the preservation of fundamental function.
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