ArticleTissue engineering. Part C, Methods2016
The Impact of Prestretch Induced Surface Anisotropy on Axon Regeneration.
Article in Tissue engineering. Part C, Methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Utilization of the Theory of Small on Large Deformation for Studying Mechanosensitive Cellular Behaviors.Journal Of Elasticity · 2019Article
- Schwann Cells Enhance Penetration of Regenerated Axons into Three-Dimensional Microchannels.Tissue engineering and regenerative medicine · 2018Article
- An Approach to Enhance Alignment and Myelination of Dorsal Root Ganglion Neurons.Journal of visualized experiments : JoVE · 2016Article
- Schwann Cells Migration on Patterned Polydimethylsiloxane Microgrooved Surface.Tissue engineering. Part C, Methods · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve regeneration after spinal cord injury requires proper axon alignment to bridge the lesion site and myelination to achieve functional recovery. Significant effort has been invested in developing engineering approaches to induce axon alignment with less focus on myelination. Topological features, such as aligned fibers and channels, have been shown to induce axon alignment, but do not enhance axon thickness. We previously demonstrated that surface anisotropy generated through mechanical prestretch induced mesenchymal stem cells to align in the direction of prestretch. In this study, we demonstrate that static prestretch-induced anisotropy promotes dorsal root ganglion (DRG) neurons to extend thicker axon aggregates along the stretched direction and form aligned fascicular-like axon tracts. Moreover, Schwann cells, when cocultured with DRG neurons on the prestretched surface colocalized with the aligned axons and expressed P0 protein, are indicative of myelination of the aligned axons, thereby demonstrating that prestretch-induced surface anisotropy is beneficial in enhancing axon alignment, growth, and myelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.