Evidence map›Paper›PMID 26563249›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2016

Measuring nonspecific factors in treatment: item banks that assess the healthcare experience and attitudes from the patient's perspective.

Carol M Greco, Lan Yu, Kelly L Johnston, Nathan E Dodds, Natalia E Morone, Ronald M Glick, Michael J Schneider, Mary Lou Klem, Christine E McFarland, Suzanne Lawrence and 5 more

5 registry-linked trialsAbstract read
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01266304 completednot on this map

The Healing Context in CAM: Instrument Development and Initial Validation

TypeobservationalSponsorUniversity of PittsburghRan2011 to 2015Enrolled72ConditionsAny Condition
NCT01904838 completednot on this map

The Healing Context in Complementary and Alternative Medicine (CAM): Instrument Development and Initial Validation - Calibration Study

TypeobservationalSponsorUniversity of PittsburghRan2012 to 2014Enrolled1,650ConditionsPersons Receiving Any Medical or Behavioral Treatment (Focus of Study is Questionnaires)
NCT02161887 completednot on this map

The Healing Context in CAM: Instrument Development and Initial Validation - Phase 3 Validation Study

TypeobservationalSponsorUniversity of PittsburghRan2014 to 2016Enrolled207ConditionsChronic Low Back Pain, Neck Pain
NCT03510117 nacompletednot on this mapstarted 2017, after this paper: background citation

Creating and Optimizing Mindfulness Measures to Enhance and Normalize Clinical Evaluation (COMMENCE)

TypeinterventionalSponsorNorthwestern UniversityRan2017 to 2022Enrolled8,152ConditionsMindfulnessArmsMindfulness
NCT05986370 narecruitingnot on this mapstarted 2023, after this paper: background citation

The METRIC Study Protocol: an Explanatory Randomized Controlled Trial Investigating the Neurophysiological Mechanisms Underlying the Therapeutic Effects of Spinal Manipulative Therapy for Chronic Primary Low Back Pain

TypeinterventionalSponsorUniversité du Québec à Trois-RivièresRan2023 to 2026Enrolled112ConditionsChronic Low-back PainArmslumbar spinal manipulative therapy, sham spinal manipulative therapy, full spine spinal manipulative therapy
3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Qualitative similarities and distinctions between participants' experiences with a yoga intervention and an attention control.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Trial
  6. Journal of alternative and complementary medicine (New York, N.Y.) · 2020
    Trial
  7. Article
  8. Article
  9. Understanding data visualization techniques in qualitative studies used to develop and validate patient-reported outcome measures: a targeted literature review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Development and calibration data for the Illness Burden item bank: a new computer adaptive test for persons with type 2 diabetes mellitus.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
  20. Development and calibration data for the Medication Adherence Item Bank: a new computer adaptive test for persons with type 2 diabetes mellitus.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carol M GrecoDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. grecocm@upmc.edu.
Lan YuDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kelly L JohnstonDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nathan E DoddsDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Natalia E MoroneDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Ronald M GlickDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael J SchneiderDepartment of Physical Therapy, University of Pittsburgh School of Health and Rehabilitation Sciences, Pittsburgh, PA, USA.
Mary Lou KlemHealth Sciences Library System, University of Pittsburgh, Pittsburgh, PA, USA.
Christine E McFarlandDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Suzanne LawrenceDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jason ColditzDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Catherine C MaihoeferDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Wayne B JonasSamueli Institute, Alexandria, VA, USA.
Neal D RyanDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Paul A PilkonisDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
The Healing Context in CAM: Instrument Development and Initial ValidationR01AT006453 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRECO, CAROL MARIE · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR000005NCCIH NIH HHS R01 AT006453NIA NIH HHS P30 AG024827
6 · The paper itself

Abstract

purposeNonspecific factors that accompany healthcare treatments, such as patients' attitudes and expectations, are important parts of the experience of care and can influence outcomes. However, no precise, concise, and generalizable instruments to measure these factors exist. We report on the development and calibration of new item banks, titled the Healing Encounters and Attitudes Lists (HEAL), that assess nonspecific factors across a broad range of treatments and conditions.

methodsThe instrument development methodology of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)) was used. Patient focus groups and clinician interviews informed our HEAL conceptual model. Literature searches of eight databases yielded over 500 instruments and resulted in an initial item pool of several thousand items. After qualitative item analysis, including cognitive interviewing, 296 items were included in field testing. The calibration sample included 1657 respondents, 1400 obtained through an Internet panel and 257 from conventional and integrative medicine clinics. Following exploratory and confirmatory factor analyses, the HEAL item banks were calibrated using item response theory.

resultsThe final HEAL item banks were Patient-Provider Connection (57 items), Healthcare Environment (25 items), Treatment Expectancy (27 items), Positive Outlook (27 items), and Spirituality (26 items). Short forms were also developed from each item bank. A six-item short form, Attitudes toward Complementary and Alternative Medicine (CAM), was also created.

conclusionsHEAL item banks provided substantial information across a broad range of each construct. HEAL item banks showed initial evidence of predictive and concurrent validity, suggesting that they are suitable for measuring nonspecific factors in treatment.

Indexed as

Complementary TherapiesDatabases as TopicPatient Reported Outcome MeasuresHumansModels, TheoreticalPsychometricsAttitude toward complementary medicineNonspecific contextual factors in treatmentPatient experience of carePatient–provider relationshipPatient-reported measuresPerceptions of the Healthcare EnvironmentPlacebo measurementPositive OutlookPROMIS instrument development methodologySpiritualityTreatment expectations

Identifiers

PMID26563249
PMCPMC4865446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.