Evidence map›Paper›PMID 26563175›Full record

ReviewScience China. Life sciences2015

Unraveling the mechanisms of synapse formation and axon regeneration: the awesome power of C. elegans genetics.

YiShi Jin

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science China. Life sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Frontiers in aging neuroscience · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

YiShi JinHoward Hughes Medical Institute, Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, CA, 92093, USA. yijin@ucsd.edu.

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Since Caenorhabditis elegans was chosen as a model organism by Sydney Brenner in 1960's, genetic studies in this organism have been instrumental in discovering the function of genes and in deciphering molecular signaling network. The small size of the organism and the simple nervous system enable the complete reconstruction of the first connectome. The stereotypic developmental program and the anatomical reproducibility of synaptic connections provide a blueprint to dissect the mechanisms underlying synapse formation. Recent technological innovation using laser surgery of single axons and in vivo imaging has also made C. elegans a new model for axon regeneration. Importantly, genes regulating synaptogenesis and axon regeneration are highly conserved in function across animal phyla. This mini-review will summarize the main approaches and the key findings in understanding the mechanisms underlying the development and maintenance of the nervous system. The impact of such findings underscores the awesome power of C. elegans genetics.

Indexed as

AnimalsAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsModels, NeurologicalMutationNerve RegenerationSignal TransductionSynapsesCaenorhabditis elegans Proteinsaxon injuryDLK kinaseEFA-6laser axotomyLiprinmicrotubule dynamicspresynaptic active zoneRPM-1SYD-2ubiquitin E3 ligase

Identifiers

PMID26563175
PMCPMC4696538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.