ArticleAnnals of biomedical engineering2016
Mapping 3D Strains with Ultrasound Speckle Tracking: Method Validation and Initial Results in Porcine Scleral Inflation.
Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Peripapillary scleral stiffening increases optic nerve head shear deformation in porcine eyes during IOP elevation.Experimental eye research · 2025Article
- Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography.Translational vision science & technology · 2025Article
- Biomechanical Correlations Between the Cornea and the Optic Nerve Head.Investigative ophthalmology & visual science · 2024Article
- Three-Dimensional Ultrasound Elastography Detects Age-Related Increase in Anterior Peripapillary Sclera and Optic Nerve Head Compression During IOP Elevation.Investigative ophthalmology & visual science · 2023Article
- Mechanical Deformation of Peripapillary Retina in Response to Acute Intraocular Pressure Elevation.Journal of biomechanical engineering · 2022Article
- High-frequency ultrasound detects biomechanical weakening in keratoconus with lower stiffness at higher grade.PloS one · 2022Article
- Regional variation of corneal stromal deformation measured by high-frequency ultrasound elastography.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Effect of different preconditioning protocols on the viscoelastic inflation response of the posterior sclera.Acta biomaterialia · 2021Article
- Heartbeat-Induced Corneal Axial Displacement and Strain Measured by High Frequency Ultrasound Elastography in Human Volunteers.Translational vision science & technology · 2020Article
- IOP-induced regional displacements in the optic nerve head and correlation with peripapillary sclera thickness.Experimental eye research · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Mechanical Deformation of Human Optic Nerve Head and Peripapillary Tissue in Response to Acute IOP Elevation.Investigative ophthalmology & visual science · 2019Article
- Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues.Journal of biomedical optics · 2018Article
- Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.Investigative ophthalmology & visual science · 2018Article
- 3D Characterization of corneal deformation using ultrasound speckle tracking.Journal of innovative optical health sciences · 2017Article
- Bovine and degenerated human annulus fibrosus: a microstructural and micromechanical comparison.Biomechanics and modeling in mechanobiology · 2017Article
- Racioethnic Differences in Human Posterior Scleral and Optic Nerve Stump Deformation.Investigative ophthalmology & visual science · 2017Article
- Whole-globe biomechanics using high-field MRI.Experimental eye research · 2017Article
- Correlation of IOP with Corneal Acoustic Impedance in Porcine Eye Model.BioMed research international · 2017Article
- Three-Dimensional Strains in Human Posterior Sclera Using Ultrasound Speckle Tracking.Journal of biomechanical engineering · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This study aimed to develop and validate a high frequency ultrasound method for measuring distributive, 3D strains in the sclera during elevations of intraocular pressure. A 3D cross-correlation based speckle-tracking algorithm was implemented to compute the 3D displacement vector and strain tensor at each tracking point. Simulated ultrasound radiofrequency data from a sclera-like structure at undeformed and deformed states with known strains were used to evaluate the accuracy and signal-to-noise ratio (SNR) of strain estimation. An experimental high frequency ultrasound (55 MHz) system was built to acquire 3D scans of porcine eyes inflated from 15 to 17 and then 19 mmHg. Simulations confirmed good strain estimation accuracy and SNR (e.g., the axial strains had less than 4.5% error with SNRs greater than 16.5 for strains from 0.005 to 0.05). Experimental data in porcine eyes showed increasing tensile, compressive, and shear strains in the posterior sclera during inflation, with a volume ratio close to one suggesting near-incompressibility. This study established the feasibility of using high frequency ultrasound speckle tracking for measuring 3D tissue strains and its potential to characterize physiological deformations in the posterior eye.
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Registered trials
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