ArticleBMC anesthesiology2015
Lung ultrasound is a reliable method for evaluating extravascular lung water volume in rodents.
Article in BMC anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Comprehensive Quantitative Assessment of Lung Liquid Clearance by Lung Ultrasound Score in Neonates with No Lung Disease during the First 24 Hours.BioMed research international · 2020Trial
- Pulmonary ultrasound provides a more accurate assessment of pulmonary congestion than wet/dry lung weight in rats.Physiological reports · 2025Article
- Lung Ultrasound Assessment of Lung Injury Following Acute Spinal Cord Injury in Rats.Diagnostics (Basel, Switzerland) · 2025Article
- Associated effects of lipopolysaccharide, oleic acid, and lung injury ventilator-induced in developing a model of moderate acute respiratory distress syndrome in New Zealand white rabbits.Frontiers in veterinary science · 2025Article
- Article
- The Correlation between Lung Ultrasound and Pathology in Rat Model of Monocrotaline-Induced Pulmonary Hypertension.Canadian respiratory journal · 2024Article
- The Rat Thoracic Ultrasound protocol: scanning technique and normal findings.Frontiers in veterinary science · 2024Article
- Ultrasound guiding the rapid diagnosis and treatment of perioperative pneumothorax: A case report.World journal of clinical cases · 2021Article
- Pulmonary edema following shoulder arthroscopy under general anesthesia with nerve block: An observational study.Medicine · 2020Observational
- From bedside to bench: lung ultrasound for the assessment of pulmonary edema in animal models.Cell and tissue research · 2020Review
- Effects of crystalloid, hyper-oncotic albumin, and iso-oncotic albumin on lung and kidney damage in experimental acute lung injury.Respiratory research · 2019Article
- Diagnostic value of cardiopulmonary ultrasound in elderly patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2018Article
- Lung ultrasound as a monitoring tool in lung transplantation in rodents: a feasibility study.Journal of thoracic disease · 2018Article
- Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.Cardiorenal medicine · 2018Article
- Lung ultrasound in acute respiratory distress syndrome and beyond.Journal of thoracic disease · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLung ultrasound (LUS) can diagnose extravacular lung water (EVLW) through the visualization of B lines in both humans and large animals. However, there are no published data on the use of ultrasound to detect EVLW in rats, the gold standard to evaluate of EVLW in rats is post-mortem gravimetric analysis. The present study was designed to determine the similarity between lung sonography and gravimetric measurements of EVLW in rats in an acute lung injury (ALI) model.
methodsThirty male Sprague-Dawley rats were randomized into control and experimental groups. The B lines were measured byLUS at baseline. ALI was induced by the intravenous administration of oleic acid (OA) at a dose of 9 ul/100 mg, and controls were injected the same amount of isotonic saline. After 1 h, B-lines were measured by LUS in each rat following the induction of ALI. At the end of each experiment, both lungs were dissected, weighed and dried to determine wet/dry weight ratio according to the standard gravimetric methodology. Lung samples from three rats in each group were examined histologically.
resultsB-lines were present in all rats from experimental group at 1 h point after OA injection. The statistical correlation between the two methods of assessing EVLW provided an r = 0.834 (p < 0.001). Repeatability studies of the LUS technique (Bland-Altman plots) showed good intra-observer and inter-observer reproducibility.
conclusionThe data suggest that, in an experimental rat model of ALI, B lines score as assessed by LUS can provide an easy, semi-quantitative, noninvasive. Real-time index of EVLW which is strongly correlated to experimental gravimetric assessments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.