ArticlePloS one2015
Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese Population.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Cocktail Therapy Combining SGLT2 Inhibitor, Entresto, and Adipose-Derived Mesenchymal Stem Cells Prevents Abdominal Aortic Aneurysmal Complication Syndrome in Rodents.Acta Cardiologica Sinica · 2026Article
- Reduced Incidence of Aortic Dissection in Patients With Type 2 Diabetes Treated With Sodium Glucose Transporter 2 Inhibitors.Journal of the American Heart Association · 2025Article
- Diabetes does not increase in-hospital or short-term mortality in patients undergoing surgical repair for type A aortic dissection: insight from the national readmission database.Cardiovascular diabetology · 2024Article
- Diabetes is not a negative prognostic factor for 30-days mortality after surgery for acute type A aortic dissection.Cardiovascular endocrinology & metabolism · 2024Article
- Causal relationship between type 2 diabetes mellitus and aortic dissection: insights from two-sample Mendelian randomization and mediation analysis.Frontiers in endocrinology · 2024Article
- A nomogram prediction model for short-term aortic-related adverse events in patients with acute Stanford type B aortic intramural hematoma: development and validation.Frontiers in cardiovascular medicine · 2024Article
- Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study.Frontiers in cardiovascular medicine · 2024Article
- Long-Term Risks of Stroke in Patients With Type A Aortic Dissection: A Nationwide Cohort Study.Journal of the American Heart Association · 2022Article
- Frozen elephant trunk in acute type A aortic dissections: frontiers and challenges.Indian journal of thoracic and cardiovascular surgery · 2022Article
- Synthesis of multidimensional pathophysiological process leading to type A aortic dissection: a narrative review.Journal of thoracic disease · 2021Review
- Root Dilatation Is More Malignant Than Ascending Aortic Dilation.Journal of the American Heart Association · 2021Article
- Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease.Frontiers in cardiovascular medicine · 2021Review
- Effect of Glycation on Interlamellar Bonding of Arterial Elastin.Experimental mechanics · 2021Article
- Reduced Long-Term Risk of Aortic Aneurysm and Aortic Dissection Among Individuals With Type 2 Diabetes Mellitus: A Nationwide Observational Study.Journal of the American Heart Association · 2018Observational
- Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study.Oncotarget · 2017Article
- Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.Annual review of medicine · 2017Review
- Autonomic remodeling may be responsible for decreased incidence of aortic dissection in STZ-induced diabetic rats via down-regulation of matrix metalloprotease 2.BMC cardiovascular disorders · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection (AD).
aimThe aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population.
methodsA hospital-based case-control study, consisting of 2160 AD patients and 4320 controls, was conducted in a Chinese population. Demographic, clinical characteristics and risk factors were collected. Diabetes rate of patients with overall AD, Stanford type A AD and type B AD group was compared with that of corresponding matched control groups. Logistic regression analysis was used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI) for relationship between diabetes and AD risk.
resultsThe prevalence of diabetes was lower in AD cases than that of control subjects, whether it is the overall AD, type A AD or type B AD group (4.7% vs. 10.0%, 2.9% vs. 8.8%, 5.9% vs. 10.9%, all P<0.001). Furthermore, in multivariate model, diabetes was found to be associated with lower AD risk, which not only applies to the overall AD (OR = 0.2, 95%CI: 0.15-0.26), but also type A AD (OR = 0.12, 95% CI: 0.07-0.20) and type B AD (OR = 0.25, 95%CI: 0.18-0.33).
conclusionsWe observed the paradoxical inverse relationship between DM and risk of AD in the Chinese population. These results suggest diabetes may play a protective role in the development of AD. However, further studies are needed to enrich related evidence, especially with regard to underlying mechanisms for these trends.
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