ArticleToxicology letters2016
Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs.
Article in Toxicology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review on the Hazard Assessment of Amorphous Silica Based on the Literature From 2013 to 2018.Frontiers in public health · 2022Pooled it
- Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles.Particle and fibre toxicology · 2025Article
- Oral Toxicity Study of Silicon Dioxide Nanoparticles on Fertility and Early Embryonic Development in Mice.International journal of nanomedicine · 2025Article
- A Comprehensive Study on Folate-Targeted Mesoporous Silica Nanoparticles Loaded with 5-Fluorouracil for the Enhanced Treatment of Gynecological Cancers.Journal of functional biomaterials · 2024Article
- Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses.Pharmaceutics · 2024Article
- Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films.ACS omega · 2022Article
- Review
- Size and surface modification of silica nanoparticles affect the severity of lung toxicity by modulating endosomal ROS generation in macrophages.Particle and fibre toxicology · 2021Article
- Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiONanomaterials (Basel, Switzerland) · 2021Article
- Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Design of Anionic Surfactant-Based Amino-Functionalized Mesoporous Silica Nanoparticles and their Application in Transdermal Drug Delivery.Pharmaceutics · 2020Article
- Size-dependent tissue-specific biological effects of core-shell structured FeJournal of nanobiotechnology · 2019Article
- RETRACTED: Reactive Mesoporous pH-Sensitive Amino-Functionalized Silica Nanoparticles for Efficient Removal of Coomassie Blue Dye.Nanomaterials (Basel, Switzerland) · 2019Article
- The Story of Nanoparticles in Differentiation of Stem Cells into Neural Cells.Neurochemical research · 2019Review
- Molecular Responses in THP-1 Macrophage-Like Cells Exposed to Diverse Nanoparticles.Nanomaterials (Basel, Switzerland) · 2019Article
- Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis.Scientific reports · 2019Article
- Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation.International journal of molecular medicine · 2019Article
- Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-β/Smad3 pathways in vivo.International journal of nanomedicine · 2019Article
- Silica nanoparticle exposure during the neonatal period impairs hippocampal precursor proliferation and social behavior later in life.International journal of nanomedicine · 2018Article
- Toxicology of silica nanoparticles: an update.Archives of toxicology · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Amorphous silica nanoparticles (NPs) possess unique material properties that make them ideal for many different applications. However, the impact of these materials on human and environmental health needs to be established. We investigated nonporous silica NPs both bare and modified with amine functional groups (3-aminopropyltriethoxysilane (APTES)) in order to evaluate the effect of surface chemistry on biocompatibility. In vitro data showed there to be little to no cytotoxicity in a human lung cancer epithelial cell line (A549) for bare silica NPs and amine-functionalized NPs using doses based on both mass concentration (below 200μg/mL) and exposed total surface area (below 14m(2)/L). To assess lung inflammation, C57BL/6 mice were administered bare or amine-functionalized silica NPs via intra-tracheal instillation. Two doses (0.1 and 0.5mg NPs/mouse) were tested using the in vivo model. At the higher dose used, bare silica NPs elicited a significantly higher inflammatory response, as evidence by increased neutrophils and total protein in bronchoalveolar lavage (BAL) fluid compared to amine-functionalized NPs. From this study, we conclude that functionalization of nonporous silica NPs with APTES molecules reduces murine lung inflammation and improves the overall biocompatibility of the nanomaterial.
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