ArticleBrain research2016
Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation.
Article in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.Brain, behavior, & immunity - health · 2026Article
- L-DOPA Induces Spatially Discrete Changes in Gene Expression in the Forebrain of Mice with a Progressive Loss of Dopaminergic Neurons.Molecular neurobiology · 2025Article
- Adolescent social isolation decreases colonic goblet cells and impairs spatial cognition through the reduction of cystine.Molecular psychiatry · 2025Article
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- Developmental Shifts in Amygdala Function.Current topics in behavioral neurosciences · 2025Review
- Central amygdala is related to the reduction of aggressive behavior by monosodium glutamate ingestion during the period of development in an ADHD model rat.Frontiers in nutrition · 2024Article
- Neurobiology of Loneliness, Isolation, and Loss: Integrating Human and Animal Perspectives.Frontiers in behavioral neuroscience · 2022Review
- TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors.EMBO reports · 2020Article
- Familiarity with social sounds alters c-Fos expression in auditory cortex and interacts with estradiol in locus coeruleus.Hearing research · 2018Article
- Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.Zoological research · 2017Review
- A novel escapable social interaction test reveals that social behavior and mPFC activation during an escapable social encounter are altered by post-weaning social isolation and are dependent on the aggressiveness of the stimulus rat.Behavioural brain research · 2017Article
- Emergence of social behavior deficit, blunted corticolimbic activity and adult depression-like behavior in a rodent model of maternal maltreatment.Translational psychiatry · 2016Article
- Development of Odor Hedonics: Experience-Dependent Ontogeny of Circuits Supporting Maternal and Predator Odor Responses in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Early life adversity has been related to a number of psychological disorders including mood and other disorders that can manifest as inappropriate or aggressive responses to social challenges. The present study used post-weaning social isolation (PSI) in rats, a model of early life adversity, to examine its effects on Fos protein expression produced by exposure to a novel social encounter. We have previously reported that the social encounter-induced increase in Fos expression in the medial prefrontal cortex observed in group-housed controls (GRP) was attenuated in rats that had experienced PSI. Here we assessed Fos expression in other brain regions thought to be involved in emotion regulation and social behavior. Male and female rats were housed in same-sex groups or in isolation (ISO) for 4 weeks beginning on postnatal day (P) 21 and were exposed to a single 15 min social encounter with a novel same-sex conspecific on P49. Fos positive cells were assessed using immunohistochemistry in 16 regions within the forebrain. Exposure to a novel conspecific increased Fos expression in the forebrain of GRP rats in a region- and sex-specific fashion. This increase was blunted or absent in ISO rats within many regions including cortical regions, thalamus, habenula, dentate gyrus, lateral septum, and basolateral amygdala. In several regions, the increase in Fos was greater in male than in female group housed rats. Negative relationships were observed between social interactions and Fos in some regions. Forebrain hypofunction produced by early-life adversity may be involved in socially inappropriate behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.