ArticleJournal of perinatology : official journal of the California Perinatal Association2016
The complete blood cell count in a refined cohort of preterm NEC: the importance of gestational age and day of diagnosis when using the CBC to estimate mortality.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The role of myeloid cells in the pathogenesis of necrotizing enterocolitis; a scoping review.Frontiers in pediatrics · 2026Review
- Predicting surgical NEC in neonates: risk factors and model development.BMC gastroenterology · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Does serum albumin at the onset of necrotisıng enterocolitis predict severe disease in preterm infants?Pediatric surgery international · 2024Article
- Assessment of inflammatory biomarkers to identify surgical/death necrotizing enterocolitis in preterm infants without pneumoperitoneum.Pediatric surgery international · 2024Article
- Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis.Pediatric research · 2024Article
- An improved joint non-negative matrix factorization for identifying surgical treatment timing of neonatal necrotizing enterocolitis.Bosnian journal of basic medical sciences · 2022Article
- Predictive factors for the surgical treatment of necrotizing enterocolitis in preterm infants: a single-center retrospective study.BMC pediatrics · 2022Article
- Association of neutropenia at disease onset with severe surgical necrotizing enterocolitis and higher mortality: A retrospective study.Frontiers in surgery · 2022Article
- Gestational Age-Specific Complete Blood Count Signatures in Necrotizing Enterocolitis.Frontiers in pediatrics · 2021Article
- Physical examination score predicts need for surgery in neonates with necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Neonatal independent predictors of severe NEC.Pediatric surgery international · 2018Article
- Identification of bacterial invasion in necrotizing enterocolitis specimens using fluorescent in situ hybridization.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Elevated fecal calprotectin levels during necrotizing enterocolitis are associated with activated neutrophils extruding neutrophil extracellular traps.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Reduction of absolute monocyte counts is associated with the severity of preterm necrotizing enterocolitis.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe value of the white blood cell count (WBC) in necrotizing enterocolitis (NEC) is controversial. One reason for this confusion may be that the various WBC lineages change substantially with increasing gestational age and thereby age of NEC onset. This study postulated that if a data set was large enough and the diagnosis of NEC clean enough, absolute WBC counts would facilitate prediction of NEC mortality. The objective of this study was to determine whether absolute WBC counts enhance the prediction of NEC mortality. STUDY
designA de-identified data subset from the Pediatrix national data set specific to the diagnoses of NEC in patients who had a CBC drawn on the day of diagnosis (exclusive of the diagnoses of spontaneous intestinal perforations and congenital anomalies) was the target for analysis. Values of primary interest included: gestation, day of diagnosis, absolute WBC count, platelet count, hematocrit, mortality and the day of diagnosis. Stepwise regression analysis was used to predict mortality.
resultA total of 4059 (79%) survivors and 1107 (21%) infants who died with a diagnosis of medical or surgical NEC were included in the data set. Associations with mortality were found with low gestational age, low platelet count, low hematocrit, high band/segmented neutrophil ratio, earlier day of diagnosis, high birth weight z-score, non-white race, no antenatal steroids in gestations above 24 weeks, absolute lymphocyte count adjusted for gestational age, and absolute monocyte count high and low values. A stepwise regression analysis yielded a receiver-operator curve of 0.819 with a sensitivity of 65% and specificity of 84%.
conclusionAbsolute WBC values enhance prediction of NEC survival when used in combination with readily available data on the day of NEC diagnosis.
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