Trial reportJournal of perinatology : official journal of the California Perinatal Association2016
Apnea of prematurity and caffeine pharmacokinetics: potential impact on hospital discharge.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Strategies for cessation of caffeine administration in preterm infants.The Cochrane database of systematic reviews · 2024Pooled it
- Discharging Preterm Infants on Caffeine-Practise Variation Across Europe: Results of a Cross-Sectional Survey.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Predictors for poor daily weight gain in preterm neonates exposed to different dose regimens of caffeine in ICU- a retrospective cohort study.BMC pediatrics · 2024Article
- Longitudinal pilot study of oxygen saturation indices in healthy preterm infants.Pediatric research · 2023Article
- The Effect of Caffeine on Heart Rate Variability in Newborns: A Pilot Study.Life (Basel, Switzerland) · 2023Article
- Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity.The Cochrane database of systematic reviews · 2023Review
- Clinical effect of different maintenance doses of caffeine citrate in the treatment of preterm infants requiring assisted ventilation: a pilot multicenter study.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Variations in length of stay among survived very preterm infants admitted to Chinese neonatal intensive care units.World journal of pediatrics : WJP · 2022Article
- The timing of withdrawal from caffeine citrate in very preterm infants.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Caffeine: cardiorespiratory effects and tissue protection in animal models.Experimental animals · 2021Review
- Immature control of breathing and apnea of prematurity: the known and unknown.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- An Evaluation of Twice-Daily Dosing of Caffeine for Apnea of Prematurity.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Caffeine in preterm infants: where are we in 2020?ERJ open research · 2020Review
- Article
- Duration and Time Trends in Hospital Stay for Very Preterm Infants Differ Across European Regions.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Observational
- Caffeine Treatment for Apnea of Prematurity and the Influence on Dose-Dependent Postnatal Weight Gain Observed Over 15 Years.Journal of caffeine and adenosine research · 2018Article
- Impact of Caffeine Boluses and Caffeine Discontinuation on Apnea and Hypoxemia in Preterm Infants.Journal of caffeine research · 2017Article
- Impact of Infant-Polysomnography Studies on Discharge Management and Outcomes: A 5 Year Experience from a Tertiary Care Unit.Journal of neonatal biology · 2017Article
- Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study.Dose-response : a publication of International Hormesis SocietyArticle
- Association of Caffeine Daily Dose With Respiratory Outcomes in Preterm Neonates: A Retrospective Cohort Study.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the half-life of serum caffeine concentrations and its relation to apnea of prematurity (AOP) after caffeine is discontinued in preparation for hospital discharge. STUDY
designProspective cohort study involving preterm infants with gestational ages ⩽33 weeks at birth. After caffeine was discontinued, serum caffeine concentrations and electronic detection of pathologic apnea, defined a priori, were obtained at 24 and 168 h, respectively.
resultCaffeine levels decreased from 13.3±3.8 to 4.3±2 mg l(-1) (n=50, mean±s.d.) at 24 and 168 h, respectively (P<0.01). The mean caffeine half-life was 87±25 h at 35±1 weeks postmenstrual age. Seven days after discontinuation of caffeine, 64% of the infants had pathologic apnea.
conclusionHospital discharge planning for preterm infants with a history of AOP should be carefully considered after discontinuing caffeine. This study showed that caffeine may not reach subtherapeutic levels until around 11-12 days.
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