Evidence map›Paper›PMID 26562096›Full record

SynthesisThe British journal of radiology2016

Dose reduction with iterative reconstruction for coronary CT angiography: a systematic review and meta-analysis.

Annemarie M Den Harder, Martin J Willemink, Quirina M B De Ruiter, Pim A De Jong, Arnold M R Schilham, Gabriel P Krestin, Tim Leiner, Ricardo P J Budde

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Trading off Iodine and Radiation Dose in Coronary Computed Tomography.Journal of cardiovascular development and disease · 2025
    Review
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  16. Cone-beam breast computed tomography using ultra-fast image reconstruction with constrained, total-variation minimization for suppression of artifacts.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Annemarie M Den Harder1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Martin J Willemink1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Quirina M B De Ruiter2 Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Pim A De Jong1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Arnold M R Schilham1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Gabriel P Krestin3 Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands.
Tim Leiner1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Ricardo P J Budde3 Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the achievable radiation dose reduction for coronary CT angiography (CCTA) with iterative reconstruction (IR) in adults and the effects on image quality.

methodsPubMed and EMBASE were searched, and original articles concerning IR for CCTA in adults using prospective electrocardiogram triggering were included. Primary outcome was the effective dose using filtered back projection (FBP) and IR. Secondary outcome was the effect of IR on objective and subjective image quality.

resultsThe search yielded 1616 unique articles, of which 10 studies (1042 patients) were included. The pooled routine effective dose with FBP was 4.2 mSv [95% confidence interval (CI) 3.5-5.0]. A dose reduction of 48% to a pooled effective dose of 2.2 mSv (95% CI 1.3-3.1) using IR was reported. Noise, contrast-to-noise ratio and subjective image quality were equal or improved in all but one study, whereas signal-to-noise ratio was decreased in two studies with IR at reduced dose.

conclusionIR allows for CCTA acquisition with an effective dose of 2.2 mSv with preserved objective and subjective image quality.

Indexed as

Radiation DosageCardiac-Gated Imaging TechniquesCoronary AngiographyHumansRadiographic Image Interpretation, Computer-AssistedSignal-To-Noise RatioTomography, X-Ray Computed

Identifiers

PMID26562096
PMCPMC4985187

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.