ArticleJournal of natural products2015
Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme.
Article in Journal of natural products, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 47 citations in OpenAlex.
- Anti-HIV diterpenoids from Daphne pseudomezereum.Phytochemistry · 2025Article
- Daphnane diterpenoid orthoesters with an odd-numbered aliphatic side chain from Daphne pedunculata.Journal of natural medicines · 2024Article
- LC-MS identification, isolation, and structural elucidation of anti-HIV macrocyclic daphnane orthoesters from Edgeworthia chrysantha.Fitoterapia · 2024Article
- Terpenoids from the Roots ofMolecules (Basel, Switzerland) · 2023Article
- Identification of Daphnane Diterpenoids fromPlants (Basel, Switzerland) · 2023Article
- Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery.Journal of natural medicines · 2023Review
- Antioxidant and Anti-Inflammatory Activities ofLife (Basel, Switzerland) · 2023Article
- Daphnepedunins A-F, Anti-HIV Macrocyclic Daphnane Orthoester Diterpenoids fromJournal of natural products · 2022Article
- Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring fromJournal of natural products · 2022Review
- Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.Journal of natural medicines · 2021Article
- Article
- Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products.Molecules (Basel, Switzerland) · 2020Review
- Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes fromJournal of natural products · 2020Article
- Natural Products Research in China From 2015 to 2016.Frontiers in chemistry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Bioassay-guided fractionation of a petroleum ether extract of the roots of Stellera chamaejasme led to the isolation of seven new (stelleralides D-J, 1-7) and 12 known (8-19) daphnane diterpenoids. The structures and relative configurations of 1-7 were established on the basis of extensive spectroscopic analysis, including HRESIMS and comprehensive NMR techniques. All isolates were evaluated for anti-HIV activity in MT4 cells. All compounds tested, except 2, showed anti-HIV activity, and, especially, five 1α-alkyldaphnane diterpenoids (3, 4, 5, 10, and 11) exhibited extremely potent anti-HIV activity, with EC50 values of 0.06-1.1 nM and selectivity index values of more than 10,000.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.