ArticleEpidemiology (Cambridge, Mass.)2016
The Impact of Multipollutant Clusters on the Association Between Fine Particulate Air Pollution and Microvascular Function.
Article in Epidemiology (Cambridge, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Hierarchical clustering for disentangling population vulnerability to asthma.Environmental advances · 2026Article
- Exposomic Determinants of Atherosclerosis: Recent Evidence.Current atherosclerosis reports · 2025Review
- A review of common statistical methods for dealing with multiple pollutant mixtures and multiple exposures.Frontiers in public health · 2024Review
- Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction.European cardiology · 2023Review
- [Combined effects of different environmental factors on health: air pollution, temperature, green spaces, pollen, and noise].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2020Review
- Probabilistic predictive principal component analysis for spatially misaligned and high-dimensional air pollution data with missing observations.Environmetrics · 2020Article
- Reactive hyperemia and baseline pulse amplitude among smelter workers exposed to fine and ultrafine particles.International archives of occupational and environmental health · 2020Article
- Time-varying associations between prenatal metal mixtures and rapid visual processing in children.Environmental health : a global access science source · 2019Article
- Associations between multipollutant day types and select cardiorespiratory outcomes in Columbia, South Carolina, 2002 to 2013.Environmental epidemiology (Philadelphia, Pa.) · 2018Article
- Long- and short-term air pollution exposure and measures of arterial stiffness in the Framingham Heart Study.Environment international · 2018Article
- Statistical Approaches to Address Multi-Pollutant Mixtures and Multiple Exposures: the State of the Science.Current environmental health reports · 2017Review
- Environmental Exposures and Cardiovascular Disease: A Challenge for Health and Development in Low- and Middle-Income Countries.Cardiology clinics · 2017Review
- Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium: The Framingham Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundPrior studies including the Framingham Heart Study have suggested associations between single components of air pollution and vascular function; however, underlying mixtures of air pollution may have distinct associations with vascular function.
methodsWe used a k-means approach to construct five distinct pollution mixtures from elemental analyses of particle filters, air pollution monitoring data, and meteorology. Exposure was modeled as an interaction between fine particle mass (PM2.5), and concurrent pollution cluster. Outcome variables were two measures of microvascular function in the fingertip in the Framingham Offspring and Third Generation cohorts from 2003 to 2008.
resultsIn 1,720 participants, associations between PM2.5 and baseline pulse amplitude tonometry differed by air pollution cluster (interaction P value 0.009). Higher PM2.5 on days with low mass concentrations but high proportion of ultrafine particles from traffic was associated with 18% (95% confidence interval: 4.6%, 33%) higher baseline pulse amplitude per 5 μg/m and days with high contributions of oil and wood combustion with 16% (95% confidence interval: 0.2%, 34%) higher baseline pulse amplitude. We observed no variation in associations of PM2.5 with hyperemic response to ischemia observed across air pollution clusters.
conclusionsPM2.5 exposure from air pollution mixtures with large contributions of local ultrafine particles from traffic, heating oil, and wood combustion was associated with higher baseline pulse amplitude but not hyperemic response. Our findings suggest little association between acute exposure to air pollution clusters reflective of select sources and hyperemic response to ischemia, but possible associations with excessive small artery pulsatility with potentially deleterious microvascular consequences.
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