Evidence map›Paper›PMID 26561982›Full record

ArticleMuscle & nerve2016

Signal recognition particle immunoglobulin g detected incidentally associates with autoimmune myopathy.

Metha Apiwattanakul, Margherita Milone, Sean J Pittock, Thomas J Kryzer, James P Fryer, Orna O'toole, Andrew Mckeon, Vanda A Lennon

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Muscle & nerve, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Metha ApiwattanakulDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
Margherita MiloneDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Sean J PittockDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
Thomas J KryzerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
James P FryerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
Orna O'tooleDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Andrew MckeonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
Vanda A LennonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.
Mayo Clinic · USToyota Motor Corporation (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionParaneoplastic autoantibody screening of 150,000 patient sera by tissue-based immunofluorescence incidentally revealed 170 with unsuspected signal recognition particle (SRP) immunoglobulin G (IgG), which is a recognized biomarker of autoimmune myopathy. Of the 77 patients with available information, 54 had myopathy. We describe the clinical/laboratory associations.

methodsDistinctive cytoplasm-binding IgG (mouse tissue substrate) prompted western blot, enzyme-linked immunoassay, and immunoprecipitation analyses. Available histories were reviewed.

resultsThe immunostaining pattern resembled rough endoplasmic reticulum, and mimicked Purkinje-cell cytoplasmic antibody type 1 IgG/anti-Yo. Immunoblotting revealed ribonucleoprotein reactivity. Recombinant antigens confirmed the following: SRP54 IgG specificity alone (17); SRP72 IgG specificity alone (3); both (32); or neither (2). Coexisting neural autoantibodies were identified in 28% (low titer). Electromyography revealed myopathy with fibrillation potentials; 78% of biopsies had active necrotizing myopathy with minimal inflammation, and 17% had inflammatory myopathy. Immunotherapy responsiveness was typically slow and incomplete, and relapses were frequent on withdrawal. Histologically confirmed cancers (17%) were primarily breast and hematologic, with some others.

conclusionsAutoimmune necrotizing SRP myopathy, both idiopathic and paraneoplastic, is underdiagnosed in neurological practice. Serological screening aids early diagnosis. Cancer surveillance and appropriate immunosuppressant therapy may improve outcome. Muscle Nerve 53: 925-932, 2016.

Indexed as

Autoimmune DiseasesMuscular DiseasesAdolescentAdultAgedAged, 80 and overAntigens, NeoplasmBrainElectromyographyEnzyme-Linked Immunosorbent AssayFemaleGlutamate DecarboxylaseHumansImmunoglobulin GImmunoprecipitationMaleAntigens, NeoplasmGlutamate Decarboxylaseglutamate decarboxylase 2Immunoglobulin GPCA-1 antigen, humanRNA, MessengerSignal Recognition Particleautoantibodynecrotizing myopathyparaneoplasticserological marker

Identifiers

PMID26561982
PMCPMC5067628
OpenAlexW2342263864

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.