Evidence map›Paper›PMID 26561932›Full record

ArticleBiomaterials2016

Successful endothelialization and remodeling of a cell-free small-diameter arterial graft in a large animal model.

Maxwell T Koobatian, Sindhu Row, Randall J Smith, Carmon Koenigsknecht, Stelios T Andreadis, Daniel D Swartz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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  17. Monocyte Recruitment for Vascular Tissue Regeneration.Advanced healthcare materials · 2022
    Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maxwell T KoobatianDepartment of Physiology and Biophysics, University at Buffalo, The State University of New York, Amherst, NY, USA.
Sindhu RowDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Randall J SmithDepartment of Biomedical Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA.
Carmon KoenigsknechtDepartment of Pediatrics, University at Buffalo, The State University of New York, Amherst, USA.
Stelios T AndreadisDepartment of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA; Department of Biomedical Engineering, University at Buffalo, The State University of New York, Amherst, NY, USA; Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA. Electronic address: sandread@buffalo.edu.
Daniel D SwartzDepartment of Physiology and Biophysics, University at Buffalo, The State University of New York, Amherst, NY, USA; Department of Pediatrics, University at Buffalo, The State University of New York, Amherst, USA; Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA. Electronic address: swartzda@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

Stem Cells for Vascular Tissue EngineeringR01HL086582 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ANDREADIS, STELIOS THEOHARIS · 2008 to 2017
$3.1M
NHLBI NIH HHS R01 HL086582
6 · The paper itself

Abstract

The large number of coronary artery bypass procedures necessitates development of off-the-shelf vascular grafts that do not require cell or tissue harvest from patients. However, immediate thrombus formation after implantation due to the absence of a healthy endothelium is very likely. Here we present the successful development of an acellular tissue engineered vessel (A-TEV) based on small intestinal submucosa that was functionalized sequentially with heparin and VEGF. A-TEVs were implanted into the carotid artery of an ovine model demonstrating high patency rates and significant host cell infiltration as early as one week post-implantation. At one month, a confluent and functional endothelium was present and the vascular wall showed significant infiltration of host smooth muscle cells exhibiting vascular contractility in response to vaso-agonists. After three months, the endothelium aligned in the direction of flow and the medial layer comprised of circumferentially aligned smooth muscle cells. A-TEVs demonstrated high elastin and collagen content as well as impressive mechanical properties and vascular contractility comparable to native arteries. This is the first demonstration of successful endothelialization, remodeling, and development of vascular function of a cell-free vascular graft that was implanted in the arterial circulation of a pre-clinical animal model.

Indexed as

Blood Vessel ProsthesisModels, AnimalAnimalsCell-Free SystemEndothelium, VascularFemaleHeparinHumansHuman Umbilical Vein Endothelial CellsSheepVascular Endothelial Growth Factor AHeparinVascular Endothelial Growth Factor ACell-free vascular graftOvine carotid modelSmall intestinal submucosaVascular endothelial growth factorVascular tissue engineering

Identifiers

PMID26561932
PMCPMC4662921
OpenAlexW2177716226

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.