Evidence map›Paper›PMID 26561831›Full record

ReviewNutrients2015

Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution.

María E Mejía-León, Ana M Calderón de la Barca

Abstract readReview
In one paragraph

Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

María E Mejía-LeónDepartment Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. esther.mejia83@gmail.com.
Ana M Calderón de la BarcaDepartment Nutrición y Metabolismo, Centro de Investigación en Alimentación y Desarrollo, A.C., Carr. La Victoria, Km. 0.6, Hermosillo, Sonora 83304, Mexico. amc@ciad.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) is the second most frequent autoimmune disease in childhood. The long-term micro- and macro-vascular complications of diabetes are associated with the leading causes of disability and even mortality in young adults. Understanding the T1D etiology will allow the design of preventive strategies to avoid or delay the T1D onset and to help to maintain control after developing. T1D development involves genetic and environmental factors, such as birth delivery mode, use of antibiotics, and diet. Gut microbiota could be the link between environmental factors, the development of autoimmunity, and T1D. In this review, we will focus on the dietary factor and its relationship with the gut microbiota in the complex process involved in autoimmunity and T1D. The molecular mechanisms involved will also be addressed, and finally, evidence-based strategies for potential primary and secondary prevention of T1D will be discussed.

Indexed as

DietGastrointestinal MicrobiomeAnimalsAutoimmune DiseasesDiabetes Mellitus, Type 1Disease Models, AnimalGastrointestinal TractHumansImmune SystemautoimmunityBacteroidesdietdysbiosisgut microbiotaType 1 diabetes

Identifiers

PMID26561831
PMCPMC4663589

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.