Evidence map›Paper›PMID 26561798›Full record

ArticleMolecules (Basel, Switzerland)2015

Synergy and Other Interactions between Polymethoxyflavones from Citrus Byproducts.

Benito F García, Ascensión Torres, Francisco A Macías

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Valorization of Taiwan'sCurrent research in food science · 2022
    Article
  4. Polyphenols from Citrus TacleMolecules (Basel, Switzerland) · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Coumarins, Xanthones and Related Compounds.Molecules (Basel, Switzerland) · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Benito F GarcíaAllelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz, C/República Saharaui n 7, 11510 Puerto Real, (Cádiz), Spain. benito.fernandez@uca.es.
Ascensión TorresAllelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz, C/República Saharaui n 7, 11510 Puerto Real, (Cádiz), Spain. chon.torres@uca.es.
Francisco A MacíasAllelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), Faculty of Science, University of Cadiz, C/República Saharaui n 7, 11510 Puerto Real, (Cádiz), Spain. famacias@uca.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The citrus by-products released from citrus processing plants may contain high levels of potentially bioactive compounds such as flavonoids, which are a widely distributed group of polyphenolic compounds with health-related properties based on their antioxidant activity. In the study reported here, the potential bioactivities and antioxidant activities of extracts, fractions and compounds from citrus by-products were evaluated along with the chemical interactions of binary mixtures of compounds and complex mixtures. The bioactivities and interactions were evaluated in wheat coleoptile bioassays and the antioxidant activity was evaluated by the al DPPH (2,2-diphenyl-1-picrylhdrazyl radical) radical scavenging assay. The extracts, fractions and most of the isolated compounds (mainly polymethoxyflavones) showed high activity in the wheat coleoptile bioassay. However, the antioxidant activity was not consistently high, except in the acetone extract fractions. Moreover, a study of the interactions with binary mixtures of polymethoxyflavones showed the occurrence of synergistic effects. The complex mixtures of fractions composed mainly of polymethoxyflavones caused a synergistic effect when it was added to a bioactive compound such as anethole. The results reported here highlight a new application for the wheat coleoptile bioassay as a quick tool to detect potential synergistic effects in compounds or mixtures.

Indexed as

CitrusDrug InteractionsDrug SynergismFlavonesFree Radical ScavengersMolecular StructurePlant ExtractsFlavonesFree Radical ScavengersPlant Extractscitrus by-productscoleoptilesDPPHflavonoidsisobolographysynergism

Identifiers

PMID26561798
PMCPMC6331868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.