ArticleJournal of neurophysiology2016
Single-trial decoding of intended eye movement goals from lateral prefrontal cortex neural ensembles.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Distinct High-Gamma Signals in Primate Prefrontal Cortex Differentiate Cue Information, Preference Revision, and Expected Reward During Value-Based Decisions.The European journal of neuroscience · 2026Article
- Mapping Eye, Arm, and Reward Information in Frontal Motor Cortices Using Electrocorticography in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mapping eye, arm, and reward information in frontal motor cortices using electrocorticography in non-human primates.bioRxiv : the preprint server for biology · 2024Article
- Intracortical brain-computer interfaces in primates: a review and outlook.Biomedical engineering letters · 2023Review
- Stable Working Memory and Perceptual Representations in Macaque Lateral Prefrontal Cortex during Naturalistic Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- A neural network for online spike classification that improves decoding accuracy.Journal of neurophysiology · 2020Article
- Motor Intention/Intentionality and Associationism - A conceptual review.Integrative psychological & behavioral science · 2018Review
- Electrical stimulation of macaque lateral prefrontal cortex modulates oculomotor behavior indicative of a disruption of top-down attention.Scientific reports · 2017Article
- Decoding of intended saccade direction in an oculomotor brain-computer interface.Journal of neural engineering · 2017Article
- Decoding subjective decisions from orbitofrontal cortex.Nature neuroscience · 2016Article
- Article
- A Normalization Circuit Underlying Coding of Spatial Attention in Primate Lateral Prefrontal Cortex.eNeuroArticle
- Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Neurons in the lateral prefrontal cortex (LPFC) encode sensory and cognitive signals, as well as commands for goal-directed actions. Therefore, the LPFC might be a good signal source for a goal-selection brain-computer interface (BCI) that decodes the intended goal of a motor action previous to its execution. As a first step in the development of a goal-selection BCI, we set out to determine if we could decode simple behavioral intentions to direct gaze to eight different locations in space from single-trial LPFC neural activity. We recorded neuronal spiking activity from microelectrode arrays implanted in area 8A of the LPFC of two adult macaques while they made visually guided saccades to one of eight targets in a center-out task. Neuronal activity encoded target location immediately after target presentation, during a delay epoch, during the execution of the saccade, and every combination thereof. Many (40%) of the neurons that encoded target location during multiple epochs preferred different locations during different epochs. Despite heterogeneous and dynamic responses, the neuronal feature set that best predicted target location was the averaged firing rates from the entire trial and it was best classified using linear discriminant analysis (63.6-96.9% in 12 sessions, mean 80.3%; information transfer rate: 21-59, mean 32.8 bits/min). Our results demonstrate that it is possible to decode intended saccade target location from single-trial LPFC activity and suggest that the LPFC is a suitable signal source for a goal-selection cognitive BCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.