ArticleJournal of neurophysiology2016
Basal forebrain dynamics during nonassociative and associative olfactory learning.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Distinct Patterns of PV and SST GABAergic Neuronal Activity in the Basal Forebrain during Olfactory-Guided Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell type-specific and frequency-dependent centrifugal modulation in olfactory bulb output neurons in vivo.Journal of neurophysiology · 2024Article
- Frequency-dependent centrifugal modulation of the activity of different classes of mitral and tufted cells in olfactory bulb.Journal of neurophysiology · 2023Article
- Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy.AIMS neuroscience · 2023Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Dynamic Cholinergic Tone in the Basal Forebrain Reflects Reward-Seeking and Reinforcement During Olfactory Behavior.Frontiers in cellular neuroscience · 2021Article
- Short-Term Plasticity in Cortical GABAergic Synapses on Olfactory Bulb Granule Cells Is Modulated by Endocannabinoids.Frontiers in cellular neuroscience · 2021Article
- Experience enhances certainty about olfactory stimuli under bulbar cholinergic control.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- The Basal Forebrain Modulates Neuronal Response in an Active Olfactory Discrimination Task.Frontiers in cellular neuroscience · 2020Article
- GABAergic Input From the Basal Forebrain Promotes the Survival of Adult-Born Neurons in the Mouse Olfactory Bulb.Frontiers in neural circuits · 2020Article
- Olfactory bulb acetylcholine release dishabituates odor responses and reinstates odor investigation.Nature communications · 2018Article
- Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Internal Cholinergic Regulation of Learning and Recall in a Model of Olfactory Processing.Frontiers in cellular neuroscience · 2016Article
- Basal Forebrain Modulation of Olfactory CodingInternational journal of psychological researchArticle
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Authors and funding
5 authors.
Funding
Abstract
Cholinergic and GABAergic projections from the horizontal diagonal band (HDB) and medial preoptic area (MCPO) of the basal forebrain to the olfactory system are associated with odor discrimination and odor learning, as well as modulation of neural responses in olfactory structures. Whereas pharmacological and lesion studies give insights into the functional role of these modulatory inputs on a slow timescale, the response dynamics of neurons in the HDB/MCPO during olfactory behaviors have not been investigated. In this study we examined how these neurons respond during two olfactory behaviors: spontaneous investigation of odorants and odor-reward association learning. We observe rich heterogeneity in the response dynamics of individual HDB/MCPO neurons, with a substantial fraction of neurons exhibiting task-related modulation. HDB/MCPO neurons show both rapid and transient responses during bouts of odor investigation and slow, long-lasting modulation of overall response rate based on behavioral demands. Specifically, baseline rates were higher during the acquisition phase of an odor-reward association than during spontaneous investigation or the recall phase of an odor reward association. Our results suggest that modulatory projections from the HDB/MCPO are poised to influence olfactory processing on multiple timescales, from hundreds of milliseconds to minutes, and are therefore capable of rapidly setting olfactory network dynamics during odor processing and learning.
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