Evidence map›Paper›PMID 26561523›Full record

SynthesisHuman molecular genetics2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Paul S de Vries, Daniel I Chasman, Maria Sabater-Lleal, Ming-Huei Chen, Jennifer E Huffman, Maristella Steri, Weihong Tang, Alexander Teumer, Riccardo E Marioni, Vera Grossmann and 121 more

Open access · bronzeAbstract readMeta-AnalysisMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Human molecular genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 7 syntheses or guidelines pooled it, 101 citations in OpenAlex.

  1. Pooled it
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  5. Genome-wide meta-analysis reveals shared newAnnals of the rheumatic diseases · 2019
    Pooled it
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  7. Pooled it
  8. Trial
  9. Article
  10. Review
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  12. Review
  13. Identification of multiple novel procoagulant plasma ligands for stabilin-2.Journal of thrombosis and haemostasis : JTH · 2025
    Article
  14. Article
  15. Article
  16. Regulation of fibrinogen synthesis.Thrombosis research · 2024
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

131 authors at 20 institutions in 23 countries.

Paul S de VriesDepartment of Epidemiology.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.
Maria Sabater-LlealDepartment of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.
Ming-Huei ChenDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA, Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA.
Jennifer E HuffmanFramingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.
Maristella SteriIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.
Weihong TangDivision of Epidemiology and Community Health and.
Alexander TeumerInstitute for Community Medicine.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, Centre for Genomic and Experimental Medicine, Queensland Brain Institute, University of Queensland, Brisbane, Australia.
Vera GrossmannCenter for Thrombosis and Hemostasis (CTH).
Jouke J HottengaDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Stella TrompetDepartment of Cardiology, Department of Gerontology and Geriatrics and.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany, DZHK (German Centre for Cardiovascular Research) and.
Jing Hua ZhaoMRC Epidemiology Unit, School of Clinical Medicine and.
Jennifer A BrodyDepartment of Medicine.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, CA, USA.
Jie Jin WangDepartment of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
Paul L AuerZilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
John R AttiaPublic Health Stream and School of Medicine and Public Health and.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tarunveer S AhluwaliaNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.
Jari LahtiInstitute of Behavioural Sciences, Folkhälsan Research Centre, Helsinki, Finland.
Cristina VenturiniInstitute of Opthalmology, UCL, London, UK, Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Lawrence F BielakDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Peter K JoshiCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.
Ares Rocanin-ArjoInstitut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.
Ivana KolcicDepartment of Public Health, Faculty of Medicine.
Pau NavarroMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Christopher OldmeadowPublic Health Stream and School of Medicine and Public Health and.
Helene RiessInstitute of Epidemiology II and.
Johanna MazurInstitute of Medical Biostatistics, Epidemiology and Informatics and.
Saonli BasuDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Anuj GoelCardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Qiong YangFramingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Mohsen GhanbariDepartment of Epidemiology, Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gonneke WillemsenDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Ann RumleyInstitute of Cardiovascular and Medical Sciences and.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.
Anton J M de CraenDepartment of Gerontology and Geriatrics and.
Anne GrotevendtInstitute of Clinical Chemistry and Laboratory Medicine.
Robert ScottMRC Epidemiology Unit, School of Clinical Medicine and.
Kent D TaylorInstitute for Translational Genomics and Population Sciences and.
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jie YaoInstitute for Translational Genomics and Population Sciences and.
Annette KifleyDepartment of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
Charles KooperbergFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Rehan QayyumDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lorna M LopezCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland, University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.
Tina L BerentzenInstitute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.
Katri RäikkönenInstitute of Behavioural Sciences.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Patricia A PeyserDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Sarah WildCentre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics.
David-Alexandre TrégouëtInstitut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.
Alan F WrightMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.
Jonathan MartenMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.
Tatijana ZemunikDepartment of Biology, School of Medicine and.
Alanna C MorrisonHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Bengt SennbladDepartment of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.
Geoffrey ToflerRoyal North Shore Hospital, Sydney University, Sydney, Australia.
Moniek P M de MaatDepartment of Hematology and.
Eco J C de GeusDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands, EMGO+ institute, VU University & VU Medical Center, Amsterdam.
Gordon D LoweInstitute of Cardiovascular and Medical Sciences and.
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.
Naveed SattarFaculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Harald BinderInstitute of Medical Biostatistics, Epidemiology and Informatics and.
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics and.
Melanie WaldenbergerInstitute of Epidemiology II and Research Unit of Molecular Epidemiology, Helmholtz ZentrumMünchen - German Research Center for Environmental Health, Neuherberg, Germany.
Kay-Tee KhawClinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Barbara McknightDepartment of Biostatistics.
Jie HuangDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
Nancy S JennyDepartment of Pathology and Laboratory Medicine and.
Elizabeth G HollidayPublic Health Stream, Hunter Medical Research Institute, School of Medicine and Public Health and.
Lihong QiDivision of Biostatistics, Department of Public Health Sciences, UC Davis, Davis, CA, USA.
Mark G McevoySchool of Medicine and Public Health, University of Newcastle, Newcastle, Australia.
Diane M BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, Alzheimer Scotland Dementia Research Centre and.
Antti-Pekka SarinInstitute for Molecular Medicine Finland (FIMM) and Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Min A JhunDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.
Anders HamstenDepartment of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.
Fernando RivadeneiraDepartment of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.
Wendy L McardleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
P Eline SlagboomDepartment of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Centre, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany.
Wolfgang KoenigGerman Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany, Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Bruce M PsatyDepartment of Medicine, Epidemiology, and Health Services and Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Talin HarituniansInflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jingmin LiuFred Hutchinson Cancer Research Center, Seattle, WA, USA.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM) and.
André G UitterlindenDepartment of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.
Albert HofmanDepartment of Epidemiology.
Oscar H FrancoDepartment of Epidemiology.
Ozren PolasekCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Department of Public Health, Faculty of Medicine, Centre for Global Health, University of Split, Split, Croatia.
Igor RudanCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.
Pierre-Emmanuel MorangeLaboratory of Haematology, La Timone Hospital, Marseille F-13385, France, INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France, Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France.
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.
Torben HansenNovo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Lewis C BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rodney J ScottInformation based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, Australia, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton Heights, Australia.
Paul MitchellDepartment of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Synlab Academy, Synlab Services LLC, Mannheim, Germany, Clinical Institute of Medical, Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
Nick J WarehamMRC Epidemiology Unit, School of Clinical Medicine and.
Annette PetersInstitute of Epidemiology II and DZHK (German Centre for Cardiovascular Research) and.
Andreas GreinacherInstitute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.
Philipp S WildCenter for Thrombosis and Hemostasis (CTH), Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Mainz, Germany.
J Wouter JukemaDepartment of Cardiology, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.
Russell TracyDepartment of Pathology and Laboratory Medicine, Center for Clinical and Translational Sciences, University of Vermont College of Medicine, Colchester, VT, USA.
Hugh WatkinsCardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Alex P ReinerFred Hutchinson Cancer Research Center, Seattle, WA, USA, University of Washington, Seattle, WA, USA.
Aaron R FolsomDivision of Epidemiology and Community Health and.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.
Christopher J O'DonnellFramingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, National Heart, Lung and Blood Institute, Division of Intramural Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK, Department of Veterans Affairs, Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA and.
David P StrachanPopulation Health Research Institute, St George's University of London, London, UK.
Abbas DehghanDepartment of Epidemiology, a.dehghan@erasmusmc.nl.
Centre for Global Health Research · CAInstitute of Genetic and Biomedical Research · ITInstitute of Genetics and Cancer · GBJohns Hopkins University · USKing's College London · GBThe University of Sydney · AUUniversity of Michigan · USBrigham and Women's Hospital · USHunter Medical Research Institute · AUInserm · FRNational Institute on Aging · USBoston University · USCentre for Human Genetics · GBErasmus MC · NLFaculty of Public Health · GBFred Hutch Cancer Center · USGenomics (United Kingdom) · GBGerman Centre for Cardiovascular Research · DEHeidelberg University · DEInstitute for Medical Informatics and Biostatistics · CH

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MARSH, LAURA · 1985 to 2007
$37.3M
Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Molecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Genotypic Determinants of Aspirin Response in High Risk FamiliesU01HL072518 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 2002 to 2008
$12.8M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Arthritis Research UKBiotechnology and Biological Sciences Research Council BB/F019394/1British Heart FoundationCancer Research UKChief Scientist Office CZB/4/505Chief Scientist Office ETM/55Department of HealthIntramural NIH HHSMedical Research Council G0000934Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G1001799Medical Research Council MC_PC_U127561128Medical Research Council MC_PC_U127592696Medical Research Council MC_U106179471Medical Research Council MC_UU_12015/1Medical Research Council MR/K026992/1Medical Research Council MR/N01104X/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA047988NCI NIH HHS CA137088NCI NIH HHS R25CA094880NCI NIH HHS UM1 CA182913NCRR NIH HHS M01-RR000052NCRR NIH HHS UL1RR025005NHGRI NIH HHS U01HG004402NHGRI NIH HHS U01-HG005152NHLBI NIH HHS HL043851NHLBI NIH HHS HL071025-01A1NHLBI NIH HHS HL080467NHLBI NIH HHS HL087660NHLBI NIH HHS HL097698NHLBI NIH HHS HL100245NHLBI NIH HHS HL59684NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01HL087652NHLBI NIH HHS R01HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01HL120393NHLBI NIH HHS R01HL59367NHLBI NIH HHS RC2 HL-102924NHLBI NIH HHS U01HL080295NHLBI NIH HHS U01 HL72518NIA NIH HHS R01AG023629NIA NIH HHS R01 AG033193NIDDK NIH HHS DK063491NIDDK NIH HHS K24 DK080140NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01DK062418NIH HHS S10 OD020069NIMH NIH HHS 1RC2 MH089951NIMH NIH HHS MH081802NIMH NIH HHS U24 MH068457-06NINDS NIH HHS NS017950NINR NIH HHS NR0224103PHS HHS R01D0042157-01AWellcome TrustWellcome Trust 068545/Z/02Wellcome Trust 076113/B/04/ZWellcome Trust FP7/2007-2013
6 · The paper itself

Abstract

Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.

Indexed as

Genetic LociPolymorphism, Single NucleotideAdultAgedAged, 80 and overFemaleFibrinogenGenome-Wide Association StudyHumansINDEL MutationMaleMiddle AgedWhite PeopleFibrinogen

Identifiers

PMID26561523
PMCPMC4715256
OpenAlexW2175426329

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.