Evidence map›Paper›PMID 26561390›Full record

Trial reportClinical and vaccine immunology : CVI2016

Persistence of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant.

Wilbur H Chen, Lisa A Jackson, Kathryn M Edwards, Wendy A Keitel, Heather Hill, Diana L Noah, C Buddy Creech, Shital M Patel, Brian Mangal, Karen L Kotloff

Open access · diamondAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Clinical and vaccine immunology : CVI, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Emerging and Pandemic Pathogens: Lessons Learned From a Clinical Research Network.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Review
  7. From Yesterday to Tomorrow: How Vaccine Platforms Have Shaped the Vaccine and Treatment Evaluation Units.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Systems Biological Analysis of Immune Response to Influenza Vaccination.Cold Spring Harbor perspectives in medicine · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Reverse Genetics Approaches for the Development of Influenza Vaccines.International journal of molecular sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Wilbur H ChenCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA wchen@medicine.umaryland.edu kkotloff@medicine.umaryland.edu.
Lisa A JacksonGroup Health Research Institute, Seattle, Washington, USA.
Kathryn M EdwardsVanderbilt Vaccine Research Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Wendy A KeitelBaylor College of Medicine, Houston, Texas, USA.
Heather HillEMMES Corporation, Rockville, Maryland, USA.
Diana L NoahSouthern Research, Birmingham, Alabama, USA.
C Buddy CreechVanderbilt Vaccine Research Program, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Shital M PatelBaylor College of Medicine, Houston, Texas, USA.
Brian MangalEMMES Corporation, Rockville, Maryland, USA.
Karen L KotloffCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, USA wchen@medicine.umaryland.edu kkotloff@medicine.umaryland.edu.
Baylor College of Medicine · USEmmes (United States) · USUniversity of Maryland, Baltimore · USVanderbilt University · USKaiser Permanente Washington Health Research Institute · USSouthern Research Institute · US

Funding

Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI OSWALD, LYNN M · 2002 to 2009
$20.2M
Clinical Research Career Development (RMI)K12RR023250 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2005 to 2009
$13.3M
NCRR NIH HHS K12 RR023250NCRR NIH HHS K12-RR-023250NCRR NIH HHS M01 RR016500NCRR NIH HHS M01-RR-016500NIAID NIH HHS HHSN272200800001CNIAID NIH HHS HHSN272200800001GNIAID NIH HHS HHSN272200800001INIAID NIH HHS HHSN272200800001ONIAID NIH HHS HHSN272200800002CNIAID NIH HHS HHSN272200800004CNIAID NIH HHS HHSN272200800013CNIAID NIH HHS HHSN272201200003IPHS HHS HHSN272200800001CPHS HHS HHSN272200800002CPHS HHS HHSN272200800004CPHS HHS HHSN27220080000CPHS HHS HHSN272200800013CPHS HHS HHSN272201200003I
6 · The paper itself

Abstract

The adjuvant AS03 is stockpiled for future formulations with new and existing vaccines for the control of pandemic influenza virus. We previously reported the immunogenicity of an A/H5N1 vaccine extemporaneously mixed with the AS03 adjuvant for 42 days following vaccination. This report extends those findings to 1 year after vaccination.

Indexed as

Adjuvants, ImmunologicAdolescentAdultalpha-TocopherolAntibodies, ViralDouble-Blind MethodDrug CombinationsFemaleHumansInfluenza A Virus, H5N1 SubtypeInfluenza, HumanInfluenza VaccinesMaleMiddle AgedPolysorbatesSqualeneAdjuvants, Immunologicalpha-TocopherolAntibodies, ViralAS03 adjuvantDrug CombinationsInfluenza VaccinesPolysorbatesSqualene

Identifiers

PMID26561390
PMCPMC4711091
OpenAlexW2229309998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.