Evidence map›Paper›PMID 26561288›Full record

ArticleNeurology2015

Tilt-induced vasovagal syncope and psychogenic pseudosyncope: Overlapping clinical entities.

Helene Blad, Robert Jan Lamberts, Gert J van Dijk, Roland D Thijs

Erratum issuedOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 59 citations in OpenAlex.

  1. Setting up an autonomic unit within the neurological department: a position statement of the European Federation of Autonomic Societies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  2. Clinical characteristics of psychogenic pseudosyncope in a population-based cohort.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  3. High prevalence of non-syncopal fainting (psychogenic pseudosyncope) in patients referred for recurrent syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Article
  4. Review
  5. A novel and practical method to add video monitoring to tilt table testing.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Helene BladFrom Stichting Epilepsie Instellingen Nederland (SEIN) (H.B., R.J.L., R.D.T.), Heemstede; and the Department of Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands.
Robert Jan LambertsFrom Stichting Epilepsie Instellingen Nederland (SEIN) (H.B., R.J.L., R.D.T.), Heemstede; and the Department of Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands.
Gert J van DijkFrom Stichting Epilepsie Instellingen Nederland (SEIN) (H.B., R.J.L., R.D.T.), Heemstede; and the Department of Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands.
Roland D ThijsFrom Stichting Epilepsie Instellingen Nederland (SEIN) (H.B., R.J.L., R.D.T.), Heemstede; and the Department of Neurology (J.G.v.D., R.D.T.), Leiden University Medical Centre, the Netherlands. rthijs@sein.nl.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the combination of tilt-induced vasovagal syncope (VVS) and psychogenic pseudosyncope (PPS) and aid its clinical recognition.

methodsWe identified people with tilt-induced VVS/PPS from 2 tertiary syncope referral centers. For each case, 3 controls with tilt-induced VVS were selected at random from the same center. Clinical characteristics were compared between both groups adjusting for multiple comparisons.

resultsOf 1,164 tilt-table tests, 23 (2%) resulted in VVS/PPS; these 23 cases were compared with 69 VVS controls. VVS and PPS coincided more often than chance would predict: 2% vs 0.6%, p < 0.001. Typical VVS prodromes and triggers were reported in all people with VVS/PPS and in controls with VVS. Attack frequency was significantly higher in the VVS/PPS (2 per month, range 0.1-60) than in the VVS group (0.25 per month, range 0.02-4; p < 0.001). Delayed recovery of consciousness was more frequently reported in the VVS/PPS group (likelihood ratio [+LR] 8.14, 95% confidence interval [CI] 3.94-16.84), as well as episodes without prodromes (+LR 5.57, 95% CI 2.53-12.26), atypical triggers (+LR 5.00, 95% CI 2.04-12.24), eye closure (+LR 3.75, 95% CI 1.68-8.35), and apparent loss of consciousness >1 minute (+LR 2.86, 95% CI 1.98-4.13).

conclusionsVVS/PPS presents with a complex phenotype. High attack frequency, delayed recovery of consciousness, apparent loss of consciousness >1 minute, ictal eye closure, atypical triggers, and the absence of prodromes may serve as indicators that PPS coincides with VVS.

Indexed as

AdolescentAdultAgedChildFemaleHumansMaleMiddle AgedRetrospective StudiesSyncopeSyncope, VasovagalTilt-Table TestYoung Adult

Identifiers

PMID26561288
PMCPMC4676758
OpenAlexW2209202140

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.