Evidence map›Paper›PMID 26560995›Full record

ReviewExpert opinion on biological therapy2016

Fabrication of tissue-engineered vascular grafts with stem cells and stem cell-derived vascular cells.

Lunchang Wang, Jiang Hu, Claire E Sorek, Eugene Y Chen, Peter X Ma, Bo Yang

Abstract readReview
In one paragraph

Review in Expert opinion on biological therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lunchang Wanga Cardiac Surgery, University of Michigan , Ann Arbor , MI , USA.
Jiang Huc Biologic and Materials Sciences, University of Michigan , Ann Arbor , MI , USA.
Claire E Soreka Cardiac Surgery, University of Michigan , Ann Arbor , MI , USA.
Eugene Y Chena Cardiac Surgery, University of Michigan , Ann Arbor , MI , USA.
Peter X Mac Biologic and Materials Sciences, University of Michigan , Ann Arbor , MI , USA.
Bo Yanga Cardiac Surgery, University of Michigan , Ann Arbor , MI , USA.

Funding

Regenerating Blood Vessels Using iPS CellsR01HL114038 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2013 to 2016
$2.1M
NHLBI NIH HHS HL114038NHLBI NIH HHS R01 HL114038
6 · The paper itself

Abstract

introductionCardiovascular disease is the leading cause of mortality worldwide. Current surgical treatments for cardiovascular disease include vascular bypass grafting and replacement with autologous blood vessels or synthetic vascular grafts. However, there is a call for better alternative biological grafts. AREAS COVERED: Tissue-engineered vascular grafts (TEVGs) are promising novel alternatives to replace diseased vessels. However, obtaining enough functional and clinically usable vascular cells for fabrication of TEVGs remains a major challenge. New findings in adult stem cells and recent advances in pluripotent stem cells have opened a new avenue for stem cell-based vascular engineering. In this review, recent advances on stem cell sourcing for TEVGs including the use of adult stem cells and pluripotent stem cells and advantages, disadvantages, and possible future implementations of different types of stem cells will be discussed. In addition, current strategies used during the fabrication of TEVGs will be highlighted. EXPERT OPINION: The application of patient-specific TEVGs constructed with vascular cells derived from immune-compatible stem cells possesses huge clinical potential. Advances in lineage-specific differentiation approaches and innovative vascular engineering strategies will promote the vascular regeneration field from bench to bedside.

Indexed as

Blood Vessel ProsthesisEndothelial CellsHematopoietic Stem CellsMyocytes, Smooth MuscleCell DifferentiationHumansMuscle, Smooth, VascularPluripotent Stem CellsTissue EngineeringAdult stem cellendothelial cellfibroblastpluripotent stem cellsmooth muscle celltissue-engineered vascular graft

Identifiers

PMID26560995
PMCPMC4928489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.