Evidence map›Paper›PMID 26560734›Full record

ArticleHepatology (Baltimore, Md.)2016

Magnetic resonance elastography is superior to acoustic radiation force impulse for the Diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: A prospective study.

Jeffrey Cui, Elhamy Heba, Carolyn Hernandez, William Haufe, Jonathan Hooker, Michael P Andre, Mark A Valasek, Hamed Aryafar, Claude B Sirlin, Rohit Loomba

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Hepatology (Baltimore, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 10 pooled it
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 10 syntheses or guidelines pooled it, 187 citations in OpenAlex.

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  19. Assessing hepatic steatosis by magnetic resonance in potential living liver donorsDiagnostic and interventional radiology (Ankara, Turkey) · 2024
    Article
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jeffrey CuiNAFLD Translational Research Unit, Department of Medicine.
Elhamy HebaLiver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, CA.
Carolyn HernandezNAFLD Translational Research Unit, Department of Medicine.
William HaufeLiver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, CA.
Jonathan HookerLiver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, CA.
Michael P AndreDepartment of Radiology, University of California, San Diego, CA.
Mark A ValasekDepartment of Pathology.
Hamed AryafarDepartment of Radiology.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California at San Diego, La Jolla, CA.
Rohit LoombaNAFLD Translational Research Unit, Department of Medicine.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
San Diego Clinical and Translational Research InstituteTL1TR000098 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2014
$860k
GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASEK23DK090303 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2011 to 2014
$721k
NCATS NIH HHS 5TL1TR000098NCATS NIH HHS TL1 TR000098NIDDK NIH HHS K23 DK090303NIDDK NIH HHS K23-DK090303NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01-DK106419
6 · The paper itself

Abstract

unlabelledMagnetic resonance elastography (MRE), an advanced magnetic resonance-based imaging technique, and acoustic radiation force impulse (ARFI), an ultrasound-based imaging technique, are accurate for diagnosing nonalcoholic fatty liver disease (NAFLD) fibrosis. However, no head-to-head comparisons between MRE and ARFI for diagnosing NAFLD fibrosis have been performed. We compared MRE versus ARFI head-to-head for diagnosing fibrosis in well-characterized patients with biopsy-proven NAFLD. This cross-sectional analysis of a prospective cohort involved 125 patients (54.4% female) who underwent MRE, ARFI, and contemporaneous liver biopsies scored using the Nonalcoholic Steatohepatitis Clinical Research Network histological scoring system. The performances of MRE versus ARFI for diagnosing fibrosis were evaluated using area under the receiver operating characteristic curves (AUROCs). The mean (± standard deviation) age and body mass index were 48.9 (±15.4) years and 31.8 (±7.0) kg/m(2) , respectively. For diagnosing any fibrosis (≥ stage 1), the MRE AUROC was 0.799 (95% confidence interval [CI] 0.723-0.875), significantly (P = 0.012) higher than the ARFI AUROC of 0.664 (95% CI 0.568-0.760). In stratified analysis by presence or absence of obesity, MRE was superior to ARFI for diagnosing any fibrosis in obese patients (P < 0.001) but not in nonobese patients (P = 0.722). The MRE AUROCs for diagnosing ≥stages 2, 3, and 4 fibrosis were 0.885 (95% CI 0.816-0.953), 0.934 (95% CI 0.863-1.000), and 0.882 (95% CI 0.729-1.000); and the ARFI AUROCs were 0.848 (95% CI 0.776-0.921), 0.896 (95% CI 0.824-0.968), and 0.862 (95% CI 0.721-1.000). MRE had higher AUROCs than ARFI for discriminating dichotomized fibrosis stages at all dichotomization cutoff points, but the AUROC differences decreased as the cutoff points (fibrosis stages) increased.

conclusionMRE is more accurate than ARFI for diagnosing any fibrosis in NAFLD patients, especially those who are obese.

Indexed as

AdultBiopsyCross-Sectional StudiesElasticity Imaging TechniquesFemaleHumansLiver CirrhosisMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseProspective Studies

Identifiers

PMID26560734
PMCPMC4818645
OpenAlexW2118283011

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.