Evidence map›Paper›PMID 26560730›Full record

ArticleEuropean radiology2016

Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition.

Daniel Ferreira, Lena Cavallin, Tobias Granberg, Olof Lindberg, Carlos Aguilar, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kłoszewska, Hilkka Soininen and 5 more

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

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  7. Sex differences in brain atrophy in dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 6 countries.

Daniel FerreiraDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 5th floor, SE-141 86, Stockholm, Sweden. daniel.ferreira.padilla@ki.se.ORCID http://orcid.org/0000-0001-9522-4338
Lena CavallinDivision of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Tobias GranbergDivision of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Olof LindbergDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 5th floor, SE-141 86, Stockholm, Sweden.
Carlos AguilarDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 5th floor, SE-141 86, Stockholm, Sweden.
Patrizia MecocciInstitute of Gerontology and Geriatrics, University of Perugia, Perugia, Italy.
Bruno VellasINSERM U 558, University of Toulouse, Toulouse, France.
Magda Tsolaki3rd Department of Neurology, Aristoteleion Panepistimeion Thessalonikis, Thessaloniki, Greece.
Iwona KłoszewskaMedical University of Lodz, Lodz, Poland.
Hilkka SoininenUniversity of Eastern Finland, University Hospital of Kuopio, Kuopio, Finland.
Simon LovestoneDepartment of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Andrew SimmonsDepartment of Neuroimaging, Institute of Psychiatry, King's College London, London, UK.
Lars-Olof WahlundDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 5th floor, SE-141 86, Stockholm, Sweden.
Eric WestmanDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Novum, 5th floor, SE-141 86, Stockholm, Sweden.
AddNeuroMed consortium and for the Alzheimer’s Disease Neuroimaging Initiative*
Karolinska Institutet · SEKarolinska University Hospital · SEInserm · FRKing's College London · GBMedical University of Lodz · PLUniversity of Eastern Finland · FIUniversity of Perugia · ITWarneford Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo validate a visual rating scale of frontal atrophy with quantitative imaging and study its association with clinical status, APOE ε4, CSF biomarkers, and cognition.

methodsThe AddNeuroMed and ADNI cohorts were combined giving a total of 329 healthy controls, 421 mild cognitive impairment patients, and 286 Alzheimer's disease (AD) patients. Thirty-four patients with frontotemporal dementia (FTD) were also included. Frontal atrophy was assessed with the frontal sub-scale of the global cortical atrophy scale (GCA-F) on T1-weighted images. Automated imaging markers of cortical volume, thickness, and surface area were evaluated. Manual tracing was also performed.

resultsThe GCA-F scale reliably reflects frontal atrophy, with orbitofrontal, dorsolateral, and motor cortices being the regions contributing most to the GCA-F ratings. GCA-F primarily reflects reductions in cortical volume and thickness, although it was able to detect reductions in surface area too. The scale showed significant associations with clinical status and cognition.

conclusionThe GCA-F scale may have implications for clinical practice as supportive diagnostic tool for disorders demonstrating predominant frontal atrophy such as FTD and the executive presentation of AD. We believe that GCA-F is feasible for use in clinical routine for the radiological assessment of dementia and other disorders. KEY POINTS: • The GCA-F visual rating scale reliably reflects frontal brain atrophy. • Orbitofrontal, dorsolateral, and motor cortices are the most contributing regions. • GCA-F shows significant associations with clinical status and cognition. • GCA-F may be supportive diagnostic tool for disorders demonstrating predominant frontal atrophy. • GCA-F may be feasible for use in radiological routine.

Indexed as

AgedAlzheimer DiseaseApolipoprotein E4BiomarkersCognitionFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedApolipoprotein E4BiomarkersAlzheimer’s diseaseFrontal atrophyFrontotemporal dementiaMild cognitive impairmentNeuroimaging

Identifiers

PMID26560730
OpenAlexW2282548079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.