Evidence map›Paper›PMID 26560729›Full record

ArticleEuropean radiology2016

Cross-national comparison of screening mammography accuracy measures in U.S., Norway, and Spain.

Laia Domingo, Solveig Hofvind, Rebecca A Hubbard, Marta Román, David Benkeser, Maria Sala, Xavier Castells

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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  6. Malmö Breast ImaginG database: objectives and development.Journal of medical imaging (Bellingham, Wash.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Laia DomingoDepartment of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Pg Marítim 25-29, 08003, Barcelona, Spain.
Solveig HofvindDepartment of Screening, Cancer Registry of Norway, P.O. 5313, Majorstua, 0304, Oslo, Norway.
Rebecca A HubbardDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, 604 Blockley Hall, 423 Guardian Dr, Philadelphia, PA, 19104, USA.
Marta RománDepartment of Screening, Cancer Registry of Norway, P.O. 5313, Majorstua, 0304, Oslo, Norway.
David BenkeserDepartment of Biostatistics, School of Public Health, University of Washington, F-600, Health Sciences Building, Seattle, WA, 98195, USA.
Maria SalaDepartment of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Pg Marítim 25-29, 08003, Barcelona, Spain.
Xavier CastellsDepartment of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Pg Marítim 25-29, 08003, Barcelona, Spain. xcastells@hospitaldelmar.cat.
Cancer Registry of Norway · NOSpanish Clinical Research Network · ESHospital Del Mar · ESUniversity of Pennsylvania · USUniversity of Washington · US

Funding

Developing Data-Driven Cancer ResearchersT32CA009168 · NCI · UNIVERSITY OF WASHINGTON · PI STEPHEN M SCHWARTZ, MICHAEL Chiao-An WU · 1985 to 2026
$10.1M
NCI NIH HHS HHSN261201100031CNCI NIH HHS T32 CA009168
6 · The paper itself

Abstract

objectiveTo compare accuracy measures for mammographic screening in Norway, Spain, and the US.

methodsInformation from women aged 50-69 years who underwent mammographic screening 1996-2009 in the US (898,418 women), Norway (527,464), and Spain (517,317) was included. Screen-detected cancer, interval cancer, and the false-positive rates, sensitivity, specificity, positive predictive value (PPV) for recalls (PPV-1), PPV for biopsies (PPV-2), 1/PPV-1 and 1/PPV-2 were computed for each country. Analyses were stratified by age, screening history, time since last screening, calendar year, and mammography modality.

resultsThe rate of screen-detected cancers was 4.5, 5.5, and 4.0 per 1000 screening exams in the US, Norway, and Spain respectively. The highest sensitivity and lowest specificity were reported in the US (83.1 % and 91.3 %, respectively), followed by Spain (79.0 % and 96.2 %) and Norway (75.5 % and 97.1 %). In Norway, Spain and the US, PPV-1 was 16.4 %, 9.8 %, and 4.9 %, and PPV-2 was 39.4 %, 38.9 %, and 25.9 %, respectively. The number of women needed to recall to detect one cancer was 20.3, 6.1, and 10.2 in the US, Norway, and Spain, respectively.

conclusionsDifferences were found across countries, suggesting that opportunistic screening may translate into higher sensitivity at the cost of lower specificity and PPV. KEY POINTS: • Positive predictive value is higher in population-based screening programmes in Spain and Norway. • Opportunistic mammography screening in the US has lower positive predictive value. • Screening settings in the US translate into higher sensitivity and lower specificity. • The clinical burden may be higher for women screened opportunistically.

Indexed as

Early Detection of CancerAgedBreastBreast NeoplasmsFemaleHumansMammographyMass ScreeningMiddle AgedMorbidityNorwayPredictive Value of TestsReproducibility of ResultsSpainUnited StatesMammographic screeningPositive predictive valueSensitivitySpecificityVariability

Identifiers

PMID26560729
PMCPMC4927608
OpenAlexW2242223957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.