ReviewCurrent opinion in clinical nutrition and metabolic care2016
Interrelationships between glutamine and citrulline metabolism.
Review in Current opinion in clinical nutrition and metabolic care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Prolonged disturbances in citrulline metabolism following resistance exercise in COPD.Clinical nutrition (Edinburgh, Scotland) · 2025Trial
- Diminished arginine bioavailability during hyperglycaemia distinguishes individuals with ADiabetologia · 2026Article
- Impaired arginine, citrulline, and glutamine metabolism in type 2 diabetes: insights from a stable isotope study.The Journal of clinical endocrinology and metabolism · 2026Article
- Phenotype-Aligned Metabolomics Identifies Plasma Arginine as a Candidate Predictor of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.Translational stroke research · 2026Article
- Article
- Arginine: at the crossroads of nitrogen metabolism.The EMBO journal · 2025Review
- Article
- Plasma amino acid signatures define types of pediatric diabetes.Clinical nutrition ESPEN · 2023Article
- Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice.Chinese medicine · 2023Article
- An untargeted metabolomic approach to investigate antiviral defence mechanisms in memory leukocytes secreting anti-SARS-CoV-2 IgG in vitro.Scientific reports · 2023Article
- Dietary supplementation with L-glutamine enhances immunity and reduces heat stress in Hanwoo steers under heat stress conditions.Journal of animal science and technology · 2022Article
- Article
- Arginase II Plays a Central Role in the Sexual Dimorphism of Arginine Metabolism in C57BL/6 Mice.The Journal of nutrition · 2020Article
- Heterotrophic Carbon Fixation in a Salamander-Alga Symbiosis.Frontiers in microbiology · 2020Article
- Citrulline Generation Test: What Does It Measure?JPEN. Journal of parenteral and enteral nutrition · 2019Article
- The Systemic Alterations of Lipids, Alanine-Glucose Cycle and Inter-Organ Amino Acid Metabolism in Swine Model Confirms the Role of Liver in Early Phase of Septic Shock.Frontiers in physiology · 2019Article
- Oxidative Modifications in Tissue Pathology and Autoimmune Disease.Antioxidants & redox signaling · 2018Review
- Diagnostic value of plasma tryptophan and symmetric dimethylarginine levels for acute kidney injury among tacrolimus-treated kidney transplant patients by targeted metabolomics analysis.Scientific reports · 2018Article
- Nutritional therapy complications in children with ultra-short bowel syndrome include growth deficiency but not cholestasis.Acta paediatrica (Oslo, Norway : 1992) · 2018Article
- Plasma Glutamine Is a Minor Precursor for the Synthesis of Citrulline: A Multispecies Study.The Journal of nutrition · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewThis article analyzes the contribution of glutamine to the synthesis of citrulline and reviews the evidence that glutamine supplementation increases citrulline production. RECENT
findingsGlutamine supplementation has been proposed in the treatment of critically ill patients; however, a recent large multicenter randomized controlled trial resulted in increased mortality in the glutamine-supplemented group. Within this context, defining the contribution of glutamine to the production of citrulline, and thus to de-novo arginine synthesis, has become a pressing issue. SUMMARY: The beneficial effects of glutamine supplementation may be partially mediated by the effects of glutamine on citrulline synthesis by the gut and the de-novo synthesis of arginine by the kidney and other tissues. Although there is no strong evidence to support that glutamine is a major precursor for citrulline synthesis in humans, glutamine has the potential to increase overall gut function and in this way increase citrulline production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.