ArticleBMC biology2015
Control of vein network topology by auxin transport.
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Multi-model GWAS reveals key loci for leaf angle in maize inbred lines from southeast China.BMC plant biology · 2026Article
- Reticulate leaf venation in Pilea peperomioides is a Voronoi diagram.Nature communications · 2026Article
- The role of auxin transport through plasmodesmata in leaf vein canalization and patterning.Frontiers in plant science · 2025Article
- Analysis of auxin responses in the fern Ceratopteris richardii identifies the developmental phase as a major determinant for response properties.Development (Cambridge, England) · 2024Article
- Mapping the membrane orientation of auxin homeostasis regulators PIN5 and PIN8 in Arabidopsis thaliana root cells reveals their divergent topology.Plant methods · 2024Article
- Control of leaf development in the water fern Ceratopteris richardii by the auxin efflux transporter CrPINMa in the CRISPR/Cas9 analysis.BMC plant biology · 2024Article
- Molecular mapping and candidate gene identification of two major quantitative trait loci associated with silique length in oilseed rape (Molecular breeding : new strategies in plant improvement · 2024Article
- Gibberellins promote polar auxin transport to regulate stem cell fate decisions in cambium.Nature plants · 2023Article
- Leaf vein patterning is regulated by the aperture of plasmodesmata intercellular channels.PLoS biology · 2022Article
- Developmental regulation of leaf venation patterns: monocot versus eudicots and the role of auxin.The New phytologist · 2022Review
- Characterization and expression profiling of PIN auxin efflux transporters reveal their role in developmental and abiotic stress conditions in rice.Frontiers in plant science · 2022Article
- Control of vein-forming, striped gene expression by auxin signaling.BMC biology · 2021Article
- Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System.Cold Spring Harbor perspectives in biology · 2021Review
- Individuality, self and sociality of vascular plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- ER-Localized PIN Carriers: Regulators of Intracellular Auxin Homeostasis.Plants (Basel, Switzerland) · 2020Review
- Plant-specific Dof transcription factors VASCULAR-RELATED DOF1 and VASCULAR-RELATED DOF2 regulate vascular cell differentiation and lignin biosynthesis in Arabidopsis.Plant molecular biology · 2020Article
- Directional auxin fluxes in plants by intramolecular domain-domain coevolution of PIN auxin transporters.The New phytologist · 2020Article
- Article
- Intracellularly Localized PIN-FORMED8 Promotes Lateral Root Emergence inFrontiers in plant science · 2019Article
- Auxin-mediated regulation of vascular patterning in Arabidopsis thaliana leaves.Plant cell reports · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue networks such as the vascular networks of plant and animal organs transport signals and nutrients in most multicellular organisms. The transport function of tissue networks depends on topological features such as the number of networks' components and the components' connectedness; yet what controls tissue network topology is largely unknown, partly because of the difficulties in quantifying the effects of genes on tissue network topology. We address this problem for the vein networks of plant leaves by introducing biologically motivated descriptors of vein network topology; we combine these descriptors with cellular imaging and molecular genetic analysis; and we apply this combination of approaches to leaves of Arabidopsis thaliana that lack function of, overexpress or misexpress combinations of four PIN-FORMED (PIN) genes--PIN1, PIN5, PIN6, and PIN8--which encode transporters of the plant signal auxin and are known to control vein network geometry.
resultsWe find that PIN1 inhibits vein formation and connection, and that PIN6 acts redundantly to PIN1 in these processes; however, the functions of PIN6 in vein formation are nonhomologous to those of PIN1, while the functions of PIN6 in vein connection are homologous to those of PIN1. We further find that PIN8 provides functions redundant and homologous to those of PIN6 in PIN1-dependent inhibition of vein formation, but that PIN8 has no functions in PIN1/PIN6-dependent inhibition of vein connection. Finally, we find that PIN5 promotes vein formation; that all the vein-formation-promoting functions of PIN5 are redundantly inhibited by PIN6 and PIN8; and that these functions of PIN5, PIN6, and PIN8 are independent of PIN1.
conclusionsOur results suggest that PIN-mediated auxin transport controls the formation of veins and their connection into networks.
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