ArticleGenome biology and evolution2015
Patterns of Gene Conversion in Duplicated Yeast Histones Suggest Strong Selection on a Coadapted Macromolecular Complex.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- POInTBMC bioinformatics · 2023Article
- Convergent evolution of polyploid genomes from across the eukaryotic tree of life.G3 (Bethesda, Md.) · 2022Article
- The contributions from the progenitor genomes of the mesopolyploid Brassiceae are evolutionarily distinct but functionally compatible.Genome research · 2021Article
- Parallel Concerted Evolution of Ribosomal Protein Genes in Fungi and Its Adaptive Significance.Molecular biology and evolution · 2020Article
- A Single, Shared Triploidy in Three Species of Parasitic Nematodes.G3 (Bethesda, Md.) · 2020Article
- Article
- Preferential retention of genes from one parental genome after polyploidy illustrates the nature and scope of the genomic conflicts induced by hybridization.PLoS genetics · 2018Article
- Rapid Gene Family Evolution of a Nematode Sperm Protein Despite Sequence Hyper-conservation.G3 (Bethesda, Md.) · 2018Article
- Phylogenomic analysis demonstrates a pattern of rare and long-lasting concerted evolution in prokaryotes.Communications biology · 2018Article
- SMORE: Synteny Modulator of Repetitive Elements.Life (Basel, Switzerland) · 2017Article
- Increased rates of protein evolution and asymmetric deceleration after the whole-genome duplication in yeasts.BMC evolutionary biology · 2017Article
- Orthologs, turn-over, and remolding of tRNAs in primates and fruit flies.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We find evidence for interlocus gene conversion in five duplicated histone genes from six yeast species. The sequences of these duplicated genes, surviving from the ancient genome duplication, show phylogenetic patterns inconsistent with the well-resolved orthology relationships inferred from a likelihood model of gene loss after the genome duplication. Instead, these paralogous genes are more closely related to each other than any is to its nearest ortholog. In addition to simulations supporting gene conversion, we also present evidence for elevated rates of radical amino acid substitutions along the branches implicated in the conversion events. As these patterns are similar to those seen in ribosomal proteins that have undergone gene conversion, we speculate that in cases where duplicated genes code for proteins that are a part of tightly interacting complexes, selection may favor the fixation of gene conversion events in order to maintain high protein identities between duplicated copies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.